Serum LDH levels may predict poor neurological outcome after aneurysmal subarachnoid hemorrhage

被引:4
作者
Cavalli, Irene [1 ,2 ]
Stella, Claudia [1 ]
Stoll, Timothee [1 ]
Mascia, Luciana [3 ]
Salvagno, Michele [1 ]
Coppalini, Giacomo [1 ]
Diosdado, Alberto [1 ]
Menozzi, Marco [1 ]
Diaferia, Daniela [1 ]
Ndieugnou Djangang, Narcisse [1 ]
Oliveira, Fernando [1 ]
Schuind, Sophie [4 ]
Taccone, Fabio Silvio [1 ]
Gouvea Bogossian, Elisa [1 ]
机构
[1] Univ Libre Bruxelles ULB, Hop Univ Bruxelles HUB, Dept Intens Care, Route Lennik 808, B-1070 Brussels, Belgium
[2] Alma Mater Studiorum Univ Bologna, Policlin St Orsola, Unit Anesthesia & Intens Care Med, Dept Med & Surg Sci, Bologna, Italy
[3] Alma Mater Studiorum Univ Bologna, Dept Biomed & Neuromotor Sci, Bologna, Italy
[4] Univ Libre Bruxelles ULB, Hop Univ Bruxelles HUB, Dept Neurosurg, Brussels, Belgium
关键词
Lactate dehydrogenase; Subarachnoid hemorrhage; Biomarker; Outcome; Functional status; LACTATE-DEHYDROGENASE; SCALE;
D O I
10.1186/s12883-023-03282-8
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
IntroductionSerum lactate dehydrogenase (LDH) levels are often elevated in cardiovascular diseases. Their prognostic role after subarachnoid hemorrhage (SAH) remains poorly evaluated.MethodsThis is a retrospective single-center study of patients with non-traumatic SAH admitted to the intensive care unit (ICU) of an University Hospital from 2007 to 2022. Exclusion criteria were pregnancy and incomplete medical records or follow-up data. Baseline information, clinical data, radiologic data, the occurrence of neurological complications as well as serum LDH levels during the first 14 days of ICU stay were collected. Unfavorable neurological outcome (UO) at 3 months was defined as a Glasgow Outcome Scale of 1-3.ResultsFive hundred and forty-seven patients were included; median serum LDH values on admission and the highest LDH values during the ICU stay were 192 [160-230] IU/L and 263 [202-351] IU/L, respectively. The highest LDH value was recorded after a median of 4 [2-10] days after ICU admission. LDH levels on admission were significantly higher in patients with UO. When compared with patients with favorable outcome (FO), patients with UO had higher serum LDH values over time. In the multivariate logistic regression model, the highest LDH value over the ICU stay (OR 1.004 [95% CI 1.002 - 1.006]) was independently associated with the occurrence of UO; the area under the receiving operator (AUROC) curve for the highest LDH value over the ICU stay showed a moderate accuracy to predict UO (AUC 0.76 [95% CI 0.72-0.80]; p < 0.001), with an optimal threshold of > 272 IU/L (69% sensitivity and 74% specificity).ConclusionsThe results in this study suggest that high serum LDH levels are associated with the occurrence of UO in SAH patients. As a readily and available biomarker, serum LDH levels should be evaluated to help with the prognostication of SAH patients.
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页数:9
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