Review of electrochemical transition-metal-catalyzed C-H functionalization reactions

The combination of organometallic C-H activation and electro-catalysis has emerged as a potent synthetic technique for various molecular scaffolds since it avoids the use of harmful and expensive chemical oxidants in stoichiometric amounts. Moreover, the pre-functionalization of substrates is not required and newer ways to perform metal-catalyzed C-H activation reactions are possible. Here, we have discussed eletrochemically driven C-H acyloxylation, acetoxylation, oxygenation, acylation, amination, alkylation, halogenation, olefinations and C-H/N-H annulation reactions using various transition-metal-catalyst such as Ru, Rh, Pd, Co, Ni, Ir, Cu, Mn and Au by anodic oxidation, followed by reductive elimination to form the corresponding C-O, C-C, C-N and C-X (X=Cl, Br, S etc.) bonds. This review covers recent developments in transition-metal-catalyzed electrochemical C-H activation from 2007 until 2022.