Antibody-Antimicrobial Conjugates for Combating Antibiotic Resistance

被引：14

作者：

Yu, Luofeng ^{[1
]}

Shang, Zifang ^{[1
,2
,3
]}

Jin, Qizhe ^{[1
]}

Chan, Siew Yin ^{[1
,4
]}

Hong, Weilin ^{[1
]}

Li, Nan ^{[1
]}

Li, Peng ^{[1
]}

机构：

[1] Northwestern Polytech Univ, Frontiers Sci Ctr Flexible Elect FSCFE, Xian Inst Biomed Mat & Engn IBME, Xian Inst Flexible Elect IFE, 127 West Youyi Rd, Xian 710072, Peoples R China

[2] Shenzhen Childrens Hosp, Inst Pediat, Shenzhen 518026, Guangdong, Peoples R China

[3] Chinese Acad Sci, Inst Microbiol, CAS Key Lab Pathogen Microbiol & Immunol, Beijing 100101, Peoples R China

[4] ASTAR, Inst Mat Res & Engn IMRE, 2 Fusionopolis Way,Innovis 08-03, Singapore 138634, Singapore

来源：

ADVANCED HEALTHCARE MATERIALS | 2023年 / 12卷 / 01期

基金：

中国国家自然科学基金;

关键词：

antibody conjugates; antimicrobial agents; antimicrobial resistance; antimicrobial peptides; nanoparticles; SITE-SPECIFIC MODIFICATION; MONOCLONAL-ANTIBODY; PSEUDOMONAS-AERUGINOSA; STAPHYLOCOCCUS-AUREUS; SELECTIVE BIOCONJUGATION; GEMTUZUMAB OZOGAMICIN; SURFACE-PROTEINS; DRUG CONJUGATE; ANTIBACTERIAL; NANOPARTICLES;

D O I：

10.1002/adhm.202202207

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

As the development of new antibiotics lags far behind the emergence of drug-resistant bacteria, alternative strategies to resolve this dilemma are urgently required. Antibody-drug conjugate is a promising therapeutic platform to delivering cytotoxic payloads precisely to target cells for efficient disease treatment. Antibody-antimicrobial conjugates (AACs) have recently attracted considerable interest from researchers as they can target bacteria in the target sites and improve the effectiveness of drugs (i.e., reduced drug dosage and adverse effects), abating the upsurge of antimicrobial resistance. In this review, the selection and progress of three essential blocks that compose the AACs: antibodies, antimicrobial payloads, and linkers are discussed. The commonly used conjugation strategies and the latest applications of AACs in recent years are also summarized. The challenges and opportunities of this booming technology are also discussed at the end of this review.

引用

页数：17

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