When autophagy meets placenta development and pregnancy complications

被引:4
|
作者
Zhou, Pei [1 ]
Wang, Junqi [1 ]
Wang, Jun [1 ,2 ]
Liu, Xiaomei [1 ]
机构
[1] China Med Univ, Shengjing Hosp, Dept Obstet & Gynecol, Shenyang, Liaoning, Peoples R China
[2] China Med Univ, Benxi Cent Hosp, Dept Obstet & Gynecol, Benxi, Liaoning, Peoples R China
来源
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | 2024年 / 12卷
基金
中国国家自然科学基金;
关键词
autophagy; placenta; pregnancy complications; gestational hypertension (GH); intrauterine growth restriction (IUGR); REGULATES AUTOPHAGY; GROWTH RESTRICTION; SIGNALING PATHWAY; DEGRADATION; MITOPHAGY; APOPTOSIS; RECEPTOR; REVEALS; PROTEIN; STRESS;
D O I
10.3389/fcell.2024.1327167
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Autophagy is a common biological phenomenon in eukaryotes that has evolved and reshaped to maintain cellular homeostasis. Under the pressure of starvation, hypoxia, and immune damage, autophagy provides energy and nutrients to cells, which benefits cell survival. In mammals, autophagy is an early embryonic nutrient supply system involved in early embryonic development, implantation, and pregnancy maintenance. Recent studies have found that autophagy imbalance in placental tissue plays a key role in the occurrence and development of pregnancy complications, such as gestational hypertension, gestational obesity, premature birth, miscarriage, and intrauterine growth restriction. This mini-review summarizes the molecular mechanism of autophagy regulation, the autophagy pathways, and related factors involved in placental tissue and comprehensively describes the role of autophagy in pregnancy complications.
引用
收藏
页数:12
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