Effect of glucagon on lipid metabolism

被引：0

作者：

Srivastava, Saurabh ^{[1
]}

Gupta, Amit ^{[2
]}

Sharma, Deepak ^{[1
]}

Maheshwari, Anuj ^{[3
]}

Shaikeh, Nadima ^{[4
]}

Sahay, Rakesh ^{[5
,6
]}

Barengo, Noel C. ^{[7
]}

机构：

[1] Govt Inst Med Sci, Dept Med, Greater Noida, Uttar Pradesh, India

[2] Ctr Diabet Care, Greater Noida, Uttar Pradesh, India

[3] Hind Inst Med Sci, Dept Med, Lucknow, Uttar Pradesh, India

[4] Natl Ctr Diabet Endocrinol & Genet NCDEG, Amman, Jordan

[5] Osmania Med Coll & Hosp, Hyderabad, Telangana, India

[6] Aster Prime Hosp, Hyderabad, Telangana, India

[7] Florida Int Univ, Herbert Wertheim Coll Med, Dept Med Educ, Div Med & Populat Hlth Sci Educ & Res, Miami, FL USA

来源：

JOURNAL OF DIABETOLOGY | 2023年 / 14卷

关键词：

Glucagon; lipid metabolism; lipolysis; MASLD;

D O I：

10.4103/jod.jod_99_23

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Glucagon is a hormone released from the alpha cells of the pancreas. It has a major role in carbohydrate metabolism. It has a major role in increasing blood glucose levels and is helpful in glycogenolysis, gluconeogenesis, and amino acid catabolism. Its role in lipid metabolism is in the form of lipolysis and beta-oxidation of fatty acids. It also has major implications in the pathogenesis of metabolic dysfunction-associated steatotic liver diseases or non-alcoholic fatty liver disease.

引用

页码：S25 / S28

页数：4

共 12 条

[1] EATON RP, 1973, J LIPID RES, V14, P312
[2] EDWARDS PA, 1979, J LIPID RES, V20, P2
[3] Glucagon Receptor Signaling and Lipid Metabolism
Galsgaard, Katrine D.
Pedersen, Jens
Knop, Filip K.
Holst, Jens J.
Albrechtsen, Nicolai J. Wewer
[J]. FRONTIERS IN PHYSIOLOGY, 2019, 10
[4] GEY F, 1977, GLUCAGON ITS ROLE PH, P517
[5] Glucagon regulates lipolysis and fatty acid oxidation through inositol triphosphate receptor 1 in the liver
Hayashi, Yoshitaka
[J]. JOURNAL OF DIABETES INVESTIGATION, 2021, 12 (01) : 32 - 34
[6] Potential roles of glucagon-like peptide-1-based therapies in treating non-alcoholic fatty liver disease
Liu, Ye
Wei, Rui
Hong, Tian-Pei
[J]. WORLD JOURNAL OF GASTROENTEROLOGY, 2014, 20 (27) : 9090 - 9097
[7] EFFECT OF GLUCAGON ON METABOLISM OF LIPIDS AND ON UREA FORMATION BY PERFUSED RAT LIVER
PENHOS, JC
DAUNAS, J
REITMAN, M
LEVINE, R
[J]. DIABETES, 1966, 15 (10) : 740 - &
[8] Glucagon stimulates gluconeogenesis by INSP3R1-mediated hepatic lipolysis
Perry, Rachel J.
Zhang, Dongyan
Guerra, Mateus T.
Brill, Allison L.
Goedeke, Leigh
Nasiri, Ali R.
Rabin-Court, Aviva
Wang, Yongliang
Peng, Liang
Dufour, Sylvie
Zhang, Ye
Zhang, Xian-Man
Butrico, Gina M.
Toussaint, Keshia
Nozaki, Yuichi
Cline, Gary W.
Petersen, Kitt Falk
Nathanson, Michael H.
Ehrlich, Barbara E.
Shulman, Gerald I.
[J]. NATURE, 2020, 579 (7798) : 279 - +
[9] Cotadutide (medi0382), a Dual Receptor Agonist with Glucagon-Like Peptide-1 and Glucagon Activity, Modulates Hepatic Glycogen and Fat Content
Robertson, Darren
Hansen, Lars
Ambery, Philip
Esterline, Russell L.
Jermutus, Lutz
Chang, Yi-Ting
Petrone, Marcella
Johansson, Edvin
Johansson, Lars
Sjoberg, Folke B.
Parker, Victoria
[J]. DIABETES, 2020, 69
[10] PROGLUCAGON IS PROCESSED TO GLUCAGON BY PROHORMONE CONVERTASE PC2 IN ALPHA-TC1-6 CELLS
ROUILLE, Y
WESTERMARK, G
MARTIN, SK
STEINER, DF
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (08) : 3242 - 3246

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