Eco-friendly green synthesis of copper nanoparticles from Tinospora cordifolia leaves: optical properties with biological evaluation of anti-microbial, anti-inflammatory and anti-oxidant applications

被引:11
|
作者
Prakash, M. V. Dass [1 ]
Sampath, Shobana [2 ]
Amudha, K. [1 ]
Nadeem, Ahmed [3 ]
Lopes, Bruno Silvester [4 ,5 ]
Durga, B. [6 ]
Muthupandian, Saravanan [7 ,8 ]
机构
[1] Sri Sankara Arts & Sci Coll, Dept Biotechnol, Kanchipuram 600091, Tamil Nadu, India
[2] Prathyusha Engn Coll, Dept Biotechnol, Chennai, Tamil Nadu, India
[3] King Saud Univ, Coll Pharm, Dept Pharmacol & Toxicol, Riyadh, Saudi Arabia
[4] Teesside Univ, Sch Hlth & Life Sci, Middlesbrough, England
[5] Teesside Univ, Natl Horizons Ctr, Darlington, England
[6] Meenakshi Acad Higher Educ & Res, Allied Hlth Sci, Chennai, Tamil Nadu, India
[7] Saveetha Inst Med & Tech Sci SIMATS, Saveetha Dent Coll, Dept Pharmacol, Chennai, Tamil Nadu, India
[8] Saveetha Inst Med & Tech Sci SIMATS, Saveetha Dent Coll, Dept Pharmacol, Kanchipuram 600077, Tamil Nadu, India
关键词
Tinospora cordifolia; copper nanoparticle; anti-microbial; anti-inflammatory; biomedical applications; RADICAL SCAVENGING ACTIVITY; OXIDE NANOPARTICLES; PHENOLIC CONTENT; IN-VITRO; ANTIBACTERIAL; EXTRACT; DYE;
D O I
10.1080/10667857.2023.2247908
中图分类号
T [工业技术];
学科分类号
08 ;
摘要
The increased use of medicinal plants has raised questions regarding their safety, efficacy, and utility. Since a result, a thorough understanding of plant phytochemical components is essential, since this information will be useful in the development of innovative therapeutic medications. Copper nanoparticles (CuNPs) have received a lot of interest due to their numerous applications. The physical and chemical features of CuNPs influence their uses. In the current study, CuNPs were synthesised utilising the chemical reduction process, with Tinospora cordifolia extract serving as a reducing agent due to their high phenolic and flavonoid content and their antibacterial and anti-inflammatory properties were also assessed. The majority of the absorption peaks found in the T. cordifolia leaves extract can also be found in the FT-IR spectrum of CuNPs, often at the same locations or with just little variations in the peak's location and intensity. Scanning Electron Microscopy (SEM) and Transmission Electron Microscopy (TEM) found that the particles were generally spherical, with an average particle size of 15 to 70 nm. Their potential as anti-bacterial and antifungal drugs was demonstrated by the antimicrobial activity, they exhibited against S. aureus (18 mm), L. bacillus (22 mm), S. mutans (24 mm), and C. albicans (15 mm). Studies on the anti-inflammatory properties of biologically produced Cu NPs were determined.
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页数:13
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