When N7-methyladenosine modification meets cancer: Emerging frontiers and promising therapeutic opportunities

被引：18
作者：
Du, Dan [1 ]
He, Jing [2 ]
Ju, Chenxi [1 ]
Wang, Chang [1 ]
Li, Hongle [3 ]
He, Fucheng [1 ]
Zhou, Mingxia [4 ]
机构：
[1] Zhengzhou Univ, Affiliated Hosp 1, Dept Med Lab, 1 East Jianshe Rd, Zhengzhou 450052, Henan, Peoples R China
[2] Zhengzhou Univ, Affiliated Hosp 1, Dept Breast Surg, Zhengzhou 450052, Peoples R China
[3] Zhengzhou Univ, Affiliated Canc Hosp, Dept Mol Pathol, Zhengzhou 450008, Henan, Peoples R China
[4] Zhengzhou Univ, Affiliated Hosp 1, Dept Gastroenterol, 1 East Jianshe Rd, Zhengzhou 450052, Peoples R China
来源：
CANCER LETTERS | 2023年 / 562卷
基金：
中国博士后科学基金; 中国国家自然科学基金;
关键词：
N7-methylguanosine(m7G); RNA modification; METTL1; WDR4; Cancer progression; 18S RIBOSOMAL-RNA; MESSENGER-RNA; BLADDER-CANCER; METHYLATION; 7-METHYLGUANOSINE; REVEALS; WBSCR22/MERM1; TRANSLATION; DIVERSITY; EFFICIENT;
D O I：
10.1016/j.canlet.2023.216165
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
N7-methylguanosine (m7G) methylation, one of the most common RNA modifications in eukaryotes, has recently gained considerable attention. The biological functions of m7G modification in RNAs, including tRNA, rRNA, mRNA, and miRNA, remain largely unknown in human diseases. Owing to rapid advances in high-throughput technologies, increasing evidence suggests that m7G modification plays a critical role in cancer initiation and progression. As m7G modification and hallmarks of cancer are inextricably linked together, targeting m7G regulators may provide new possibilities for future cancer diagnoses and potential intervention targets. This review summarizes various detection methods for m7G modification, recent advances in m7G modification and tumor biology regarding their interplay and regulatory mechanisms. We conclude with an outlook on the future of diagnosing and treating m7G-related diseases.
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页数：12
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