The global burden of metabolic disease: Data from 2000 to 2019

被引：445

作者：

Chew, Nicholas W. S. ^{[1
]}

Ng, Cheng Han ^{[2
]}

Tan, Darren Jun Hao ^{[2
]}

Kong, Gwyneth ^{[2
]}

Lin, Chaoxing ^{[2
]}

Chin, Yip Han ^{[2
]}

Lim, Wen Hui ^{[2
]}

Huang, Daniel Q. ^{[2
,3
,4
]}

Quek, Jingxuan ^{[2
]}

Fu, Clarissa Elysia ^{[2
]}

Xiao, Jieling ^{[2
]}

Syn, Nicholas ^{[2
,5
]}

Foo, Roger ^{[1
,2
]}

Khoo, Chin Meng ^{[2
,6
]}

Wang, Jiong-Wei ^{[7
,8
,9
]}

Dimitriadis, Georgios K. ^{[10
,11
]}

Young, Dan Yock ^{[2
,3
,4
]}

Siddiqui, Mohammad Shadab ^{[12
]}

Lam, Carolyn S. P. ^{[13
,14
]}

Wang, Yibin ^{[14
]}

Figtree, Gemma A. ^{[15
,16
]}

Chan, Mark Y. ^{[1
,2
]}

Cummings, David E. ^{[17
]}

Noureddin, Mazen ^{[18
]}

Wong, Vincent Wai-Sun ^{[19
]}

Wan Ma, Ronald Ching ^{[19
,20
,21
]}

Mantzoros, Christos S. ^{[22
,23
]}

Sanyal, Arun ^{[12
]}

Muthiah, Mark Dhinesh ^{[2
,3
,4
]}

机构：

[1] Natl Univ Hlth Syst, Natl Univ Heart Ctr, Dept Cardiol, Singapore, Singapore

[2] Natl Univ Singapore, Yong Loo Lin Sch Med, Singapore, Singapore

[3] Natl Univ Singapore Hosp, Dept Med, Div Gastroenterol & Hepatol, Singapore, Singapore

[4] Natl Univ Hlth Syst, Natl Univ Ctr Organ Transplantat, Singapore, Singapore

[5] Univ Surg Cluster, Natl Univ Hosp, Div Gen Surg, Singapore, Singapore

[6] Natl Univ Singapore Hosp, Dept Med, Div Endocrinol, Singapore, Singapore

[7] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Surg, Singapore, Singapore

[8] Natl Univ Hlth Syst, Natl Univ Heart Ctr, Cardiovasc Res Inst, Singapore, Singapore

[9] Natl Univ Singapore, Ctr NanoMed, Yong Loo Lin Sch Med, Nanomed Translat Res Programme, Singapore, Singapore

[10] Kings Coll Hosp NHS Fdn Trust, ASO Easo COM, Dept Endocrinol, Denmark Hill, London, England

[11] Kings Coll London, Fac Cardiovasc Med & Sci, Sch Life Course Sci, Dept Diabet,Obes Type Diabet & Immunometab Res Grp, London, England

[12] Virginia Commonwealth Univ, Dept Internal Med, Div Gastroenterol Hepatol & Nutr, Richmond, VA USA

[13] Natl Heart Ctr Singapore, Singapore, Singapore

[14] Duke NUS Med Sch, Singapore, Singapore

[15] Univ Sydney, Kolling Inst Med Res, Northern Clin Sch, Sydney, NSW, Australia

[16] Royal North Shore Hosp, Dept Cardiol, Sydney, NSW, Australia

[17] Univ Washington, UW Med Diabet Inst, VA Puget Sound Hlth Care Syst, Seattle, WA USA

[18] Houston Res Inst, Houston, TX USA

[19] Chinese Univ Hong Kong, Dept Med & Therapeut, Hong Kong, Peoples R China

[20] Chinese Univ Hong Kong, Li Ka Shing Inst Hlth Sci, Hong Kong, Peoples R China

[21] Chinese Univ Hong Kong, Hong Kong Inst Diabet & Obes, Hong Kong, Peoples R China

[22] Boston VA Healthcare Syst, Sect Endocrinol, Boston, MA USA

[23] Harvard Univ, Fac Med, Boston, MA USA

来源：

CELL METABOLISM | 2023年 / 35卷 / 03期

关键词：

FATTY LIVER-DISEASE; BODY-MASS INDEX; RISK-FACTORS; OBESITY; HEALTH; HYPERTENSION; ASSOCIATION; OVERWEIGHT; MANAGEMENT; COUNTRIES;

D O I：

10.1016/j.cmet.2023.02.003

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Global estimates of prevalence, deaths, and disability-adjusted life years (DALYs) from the Global Burden of Diseases, Injuries, and Risk Factors Study 2019 were examined for metabolic diseases (type 2 diabetes mel-litus [T2DM], hypertension, and non-alcoholic fatty liver disease [NAFLD]). For metabolic risk factors (hyper-lipidemia and obesity), estimates were limited to mortality and DALYs. From 2000 to 2019, prevalence rates increased for all metabolic diseases, with the greatest increase in high socio-demographic index (SDI) coun-tries. Mortality rates decreased over time in hyperlipidemia, hypertension, and NAFLD, but not in T2DM and obesity. The highest mortality was found in the World Health Organization Eastern Mediterranean region, and low to low-middle SDI countries. The global prevalence of metabolic diseases has risen over the past two decades regardless of SDI. Urgent attention is needed to address the unchanging mortality rates attributed to metabolic disease and the entrenched sex-regional-socioeconomic disparities in mortality.

引用

页码：414 / +

页数：19

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