Association Between the Neutrophil-to-Lymphocyte Ratio and Infection and Survival in Diffuse Large B Cell Lymphoma

被引:2
|
作者
Shih, Min-feng [1 ,2 ]
Lue, Kun-han [3 ]
Wang, Tso-fu [4 ,5 ]
Chu, Sung-chao [4 ,5 ]
Huang, Chun-hou [2 ,6 ]
机构
[1] Hualien Tzu Chi Hosp, Buddhist Tzu Chi Med Fdn, Dept Nursing, Hualien, Taiwan
[2] Tzu Chi Univ, Dept Nursing, Hualien, Taiwan
[3] Tzu Chi Univ Sci & Technol, Dept Med Imaging & Radiol Sci, Hualien, Taiwan
[4] Hualien Tzu Chi Hosp, Buddhist Tzu Chi Med Fdn, Dept Hematol & Oncol, Hualien, Taiwan
[5] Tzu Chi Univ, Sch Med, Hualien, Taiwan
[6] Tzu Chi Univ, Dept Nursing, 701,Sec 3, Zhongyang Rd, Hualien 970374, Taiwan
来源
IN VIVO | 2023年 / 37卷 / 02期
关键词
Neutrophil-to-lymphocyte ratio; sarcopenia; frailty; infection; diffuse large B cell lymphoma; MODIFIED FRAILTY INDEX; FEBRILE NEUTROPENIA; R-CHOP; CHEMOTHERAPY; MORTALITY;
D O I
10.21873/invivo.13167
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Background/Aim: Infection is a common cause of morbidity and mortality in patients treated for diffuse large B -cell lymphoma (DLBCL). However, there is limited information on the impact and risk factors for infection among patients receiving rituximab, cyclophosphamide, vincristine, doxorubicin, and prednisolone (R-CHOP). Patients and Methods: A retrospective study evaluating patients with DLBCL receiving R -CHOP and R-COP between 2004 and 2021 was conducted at a medical center. Hospital patients' records for the five-item modified frailty index (mFI-5), sarcopenia, blood-based inflammatory markers, and clinical outcomes were statistically analyzed. Results: Patients with frailty, sarcopenia, and high neutrophil-to-lymphocyte ratio (NLR) were associated with a higher risk of infections. The revised International Prognostic Index poor-risk group, high NLR, infections, and treatment modality were risk factors for shorter progression-free and overall survival. Conclusion: Pre-treatment high NLR was a predictor of infection and survival outcome in DLBCL patients.
引用
收藏
页码:948 / 954
页数:7
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