Efficacy of Cinacalcet Combined with Calcitriol in Treating Hemodialysis Patients with Secondary Hyperparathyroidism and Its Effect on Calcium and Phosphorus Metabolism

The efficacy of cinacalcet combined with calcitriol in treating hemodialysis patients with secondary hyperparathyroidism (SHPT) and its effect on calcium and phosphorus metabolismaimed were investigated. Sixty-four uremic hemodialysis patients with SHPT were randomized to the control and experimental groups. During the whole hemodialysis period, the control group was given calcitriol. Based on the control group, the experimental group was treated with cinacalcet hydrochloride. After 6 months of treatment, total effective rate of experimental group was obviously higher than the control group. At the time 3 and 6 months after treatment, the serum calcium, phosphorus and parathyroid hormone levels in experimental group remarkably lower comparing to control group. The blood urea nitrogen and serum creatinine levels presented no obvious difference among two groups, with no obvious difference of adverse reaction incidence between them. In conclusion, cinacalcet combined with calcitriol has accurate efficacy in treating hemodialysis patients with SHPT. It can significantly reduce the parathyroid hormone level and alleviate the calcium and phosphorus metabolism disorder, with good safety. RESUMEN. Se investigo la eficacia de cinacalcet combinado con calcitriol en el tratamiento de pacientes en hemodialisis con hiperparatiroidismo secundario (HPTS) y su efecto sobre el metabolismo del calcio y fosforo. Sesenta y cuatro pacientes de hemodialisis uremica con SHPT fueron asignados al azar a los grupos de control y experimental. Durante todo el penodo de hemodialisis, el grupo control recibio calcitriol. En base al grupo control, el grupo experimental fue tratado con clorhidrato de cinacalcet. Despues de 6 meses de tratamiento, la tasa efectiva total del grupo experimental fue obviamente mas alta que la del grupo de control. A los 3 y 6 meses despues del tratamiento, los en comparacion con el grupo de control. Los niveles de nitrogeno ureico en sangre y creatinina serica no presentaron diferencias obvias entre los dos grupos, sin diferencias obvias en la incidencia de reacciones adversas entre ellos. En conclusion, cinacalcet combinado con calcitriol tiene una eficacia certera en el tratamiento de pacientes en he