Targeting of a New Node in Lipid Metabolism as a Potential Treatment Strategy for ACC

被引：2
作者：
LaPensee, Christopher R. [1 ,2 ]
Hammer, Gary D. [1 ]
机构：
[1] Univ Michigan, Dept Internal Med, Div Metab Endocrinol & Diabet, Ann Arbor, MI 48106 USA
[2] Univ Michigan, Dept Internal Med, Div Metab Endocrinol & Diabet, 109 Zina Pitcher Pl, Ann Arbor, MI 48109 USA
来源：
ENDOCRINOLOGY | 2023年 / 164卷 / 03期
关键词：
adrenal; cancer; lipid; cholesterol; APOPTOSIS;
D O I：
10.1210/endocr/bqad003
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
引用
收藏
页数：2
相关论文
共 9 条
  • [1] Potentiation of mitotane action by rosuvastatin: New insights for adrenocortical carcinoma management
    Boulate, Geoffrey
    Amazit, Larbi
    Naman, Annabelle
    Seck, Atmane
    Paci, Angelo
    Lombes, Anne
    Pussard, Eric
    Baudin, Eric
    Lombes, Marc
    Hescot, Segolene
    [J]. INTERNATIONAL JOURNAL OF ONCOLOGY, 2019, 54 (06) : 2149 - 2156
  • [2] Lipids and cancer: Emerging roles in pathogenesis, diagnosis and therapeutic intervention
    Butler, Lisa M.
    Perone, Ylenia
    Dehairs, Jonas
    Lupien, Leslie E.
    de Laat, Vincent
    Talebi, Ali
    Loda, Massimo
    Kinlaw, William B.
    Swinnen, Johannes V.
    [J]. ADVANCED DRUG DELIVERY REVIEWS, 2020, 159 : 245 - 293
  • [3] Adrenocortical Carcinoma
    Else, Tobias
    Kim, Alex C.
    Sabolch, Aaron
    Raymond, Victoria M.
    Kandathil, Asha
    Caoili, Elaine M.
    Jolly, Shruti
    Miller, Barbra S.
    Giordano, Thomas J.
    Hammer, Gary D.
    [J]. ENDOCRINE REVIEWS, 2014, 35 (02) : 282 - 326
  • [4] Lipoprotein-Free Mitotane Exerts High Cytotoxic Activity in Adrenocortical Carcinoma
    Hescot, Segolene
    Seck, Atmane
    Guerin, Maryse
    Cockenpot, Florence
    Huby, Thierry
    Broutin, Sophie
    Young, Jacques
    Paci, Angelo
    Baudin, Eric
    Lombes, Marc
    [J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2015, 100 (08) : 2890 - 2898
  • [5] ATR-101, a Selective and Potent Inhibitor of Acyl-CoA Acyltransferase 1, Induces Apoptosis in H295R Adrenocortical Cells and in the Adrenal Cortex of Dogs
    LaPensee, Christopher R.
    Mann, Jacqueline E.
    Rainey, William E.
    Crudo, Valentina
    Hunt, Stephen W., III
    Hammer, Gary D.
    [J]. ENDOCRINOLOGY, 2016, 157 (05) : 1775 - 1788
  • [6] Mitotane Inhibits Sterol-O-Acyl Transferase 1 Triggering Lipid-Mediated Endoplasmic Reticulum Stress and Apoptosis in Adrenocortical Carcinoma Cells
    Sbiera, Silviu
    Leich, Ellen
    Liebisch, Gerhard
    Sbiera, Iuliu
    Schirbel, Andreas
    Wiemer, Laura
    Matysik, Silke
    Eckhardt, Carolin
    Gardill, Felix
    Gehl, Annemarie
    Kendl, Sabine
    Weigand, Isabel
    Bala, Margarita
    Ronchi, Cristina L.
    Deutschbein, Timo
    Schmitz, Gerd
    Rosenwald, Andreas
    Allolio, Bruno
    Fassnacht, Martin
    Kroiss, Matthias
    [J]. ENDOCRINOLOGY, 2015, 156 (11) : 3895 - 3908
  • [7] A phase 1 study of nevanimibe HCl, a novel adrenal-specific sterol O-acyltransferase 1 (SOAT1) inhibitor, in adrenocortical carcinoma
    Smith, David C.
    Kroiss, Matthias
    Kebebew, Electron
    Habra, Mouhammed Amir
    Chugh, Rashmi
    Schneider, Bryan J.
    Fassnacht, Martin
    Jafarinasabian, Pegah
    Ijzerman, M. Marian
    Lin, Vivian H.
    Mohideen, Pharis
    Naing, Aung
    [J]. INVESTIGATIONAL NEW DRUGS, 2020, 38 (05) : 1421 - 1429
  • [8] Mitotane Targets Lipid Droplets to Induce Lipolysis in Adrenocortical Carcinoma
    Warde, Kate M.
    Lim, Yi Jan
    Ribes Martinez, Eduardo
    Beuschlein, Felix
    O'Shea, Paula
    Hantel, Constanze
    Dennedy, Michael Conall
    [J]. ENDOCRINOLOGY, 2022, 163 (09)
  • [9] Liver X receptor inhibition potentiates mitotane-induced adrenotoxicity in ACC
    Warde, Kate M.
    Schoenmakers, Erik
    Martinez, Eduardo Ribes
    Lim, Yi Jan
    Leonard, Maeve
    Lawless, Sarah J.
    O'Shea, Paula
    Chatterjee, Krishna, V
    Gurnell, Mark
    Hantel, Constanze
    Dennedy, Michael Conall
    [J]. ENDOCRINE-RELATED CANCER, 2020, 27 (06) : 361 - 373
1