The Emerging Roles of E3 Ligases and DUBs in Neurodegenerative Diseases

被引：16

作者：

Liu, Na ^{[1
,2
]}

Lin, Miao-Miao ^{[1
,2
]}

Wang, Yan ^{[1
,2
]}

机构：

[1] Soochow Univ, Dept Pharmacol, Coll Pharmaceut Sci, Suzhou Key Lab Aging & Nervous Dis, Suzhou, Jiangsu, Peoples R China

[2] Soochow Univ, Jiangsu Key Lab Neuropsychiat Dis, Suzhou, Jiangsu, Peoples R China

来源：

MOLECULAR NEUROBIOLOGY | 2023年 / 60卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Neurodegenerative diseases; Ubiquitination; E3 ubiquitin ligases; Deubiquitinating enzymes; ALPHA-SYNUCLEIN TOXICITY; AMYOTROPHIC-LATERAL-SCLEROSIS; MUTANT HUNTINGTIN TOXICITY; PROTEIN-QUALITY CONTROL; C-TERMINAL HYDROLASE; PARKINSONS-DISEASE; DEUBIQUITINATING ENZYME; UBIQUITIN LIGASE; PROTEASOME ACTIVITY; SIGNALING PATHWAY;

D O I：

10.1007/s12035-022-03063-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Despite annual increases in the incidence and prevalence of neurodegenerative diseases, there is a lack of effective treatment strategies. An increasing number of E3 ubiquitin ligases (E3s) and deubiquitinating enzymes (DUBs) have been observed to participate in the pathogenesis mechanisms of neurodegenerative diseases, on the basis of which we conducted a systematic literature review of the studies. This review will help to explore promising therapeutic targets from highly dynamic ubiquitination modification processes.

引用

页码：247 / 263

页数：17

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