Host-microbiome interactions in atopic and allergic diseases

被引：3

作者：

Fyhrquist, Nanna ^{[1
]}

Werner, Paulina ^{[1
]}

Alenius, Harri ^{[1
,2
]}

机构：

[1] Karolinska Inst, Inst Environm Med, Stockholm, Sweden

[2] Univ Helsinki, Human Microbiome Res Program HUMI, Helsinki, Finland

来源：

CURRENT OPINION IN TOXICOLOGY | 2023年 / 35卷

基金：

瑞典研究理事会;

关键词：

Exposome; Microbiome; Immunity; Epithelial barrier; Allergy; GUT MICROBIOTA; RETINOIC ACID; IMPACT; EXPOSOME; IMMUNITY; HEALTH;

D O I：

10.1016/j.cotox.2023.100420

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

The environmental exposome impacts the human microbiome, which in turn influences various immune and metabolic functions. Microbiome dysbiosis can be triggered by exposome components and may lead to the development of atopies or exacerbation of existing allergic conditions via the disruption of epithelial barriers and alteration of immune responses. The gut microbiome is a key regulator of the immune system, and immune homeostasis is maintained through bidirectional communication between the gut and distant tissues and organs. The skin microbiome also plays a central role in tuning host immunity and may contribute significantly to the emergence and progression of allergic skin disease. The loss of balance between the host and its microbiota can lead to the breakdown of immune tolerance and may thus contribute to allergy development. In this review, we discuss the current understanding of host-microbe and environmental interactions which have been linked with atopy and allergic diseases.

引用

页数：8

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