Association between adjuvant chemotherapy and survival in stage I gastric cancer patients after curative resection

被引:0
|
作者
Chen, Qiuying [1 ,2 ]
Xiao, Hua [3 ,4 ]
Zhang, Lu [1 ,2 ]
You, Jingjing [1 ,2 ]
Jin, Zhe [1 ,2 ]
Zhang, Bin [1 ,2 ]
机构
[1] Jinan Univ, Affiliated Hosp 1, Dept Radiol, 613 Huangpu West Rd, Guangzhou 510627, Guangdong, Peoples R China
[2] Jinan Univ, Grad Coll, Guangzhou, Guangdong, Peoples R China
[3] Cent South Univ, Xiangya Sch Med, Hunan Canc Hosp, Dept Hepatobiliary & Intestinal Surg, Changsha, Hunan, Peoples R China
[4] Cent South Univ, Xiangya Sch Med, Affiliated Canc Hosp, Changsha, Hunan, Peoples R China
来源
GASTROENTEROLOGY REPORT | 2023年 / 11卷
关键词
gastric cancer; stage I; survival; adjuvant chemotherapy; propensity score matching; POSTOPERATIVE CHEMOTHERAPY; PROGNOSTIC-FACTORS; RISK-FACTORS; S-1; GASTRECTOMY; RECURRENCE; INVASION; OUTCOMES; TRIAL;
D O I
10.1093/gastro/goad070
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Background The efficacy of adjuvant chemotherapy (AC) on survival outcomes of patients with stage I gastric cancer (GC) after curative resection remains controversial. We aimed to determine whether these patients would benefit from AC.Methods This retrospective study included patients with pathologically confirmed stage I GC who underwent curative resection between November 2010 and December 2020. Patients were divided into AC and non-AC groups, then a 1:1 propensity score matching (PSM) analysis was performed to minimize the selection bias. Potential risk factors including age, pN stage, pT stage, lymphovascular invasion, perineural invasion, tumor size, histological type, and carcinoembryonic antigen level were used as matching covariates. The recurrence-free survival (RFS) and disease-specific survival (DSS) were compared between groups using the Kaplan-Meier method.Results A total of 902 consecutive patients were enrolled and 174 (19.3%) patients were treated with AC. PSM created 123 pairs of patients. Before PSM, patients receiving AC had lower 10-year RFS rates (90% vs 94.6%, P = 0.035) than those who did not receive AC; the two groups had similar 10-year DSS rates (93.8% vs 95.0%, P = 0.240). After PSM, there were no statistical differences in the 10-year RFS (90.9% vs 93.0%, P = 0.507) or DSS rates (93.5% vs 93.6%, P = 0.811) between the two groups. Similar results were found in the stage IA and IB subgroups. Moreover, these findings were not affected by AC cycles.Conclusions The addition of AC could not provide survival benefits for patients with stage I GC after surgery and follow-up is thus recommended. However, large-scale randomized clinical trials are required.
引用
收藏
页数:7
相关论文
共 50 条
  • [21] Changing Pattern of Postoperative Body Weight and its Association with Recurrence and Survival after Curative Resection for Gastric Cancer
    Lee, Sang Eok
    Lee, Jun Ho
    Ryu, Keun Won
    Byungho-Nam
    Kim, Chan Gyoo
    Park, Sook Ryun
    Kook, Myeong-Cherl
    Kim, Young-Woo
    HEPATO-GASTROENTEROLOGY, 2012, 59 (114) : 430 - 435
  • [22] Adjuvant chemotherapy may improve prognosis after resection of stage I lung cancer with lymphovascular invasion
    Wang, Shuyuan
    Xu, Jianlin
    Wang, Rui
    Qian, Fangfei
    Yang, Wenjia
    Qiao, Rong
    Zhang, Bo
    Qian, Jie
    Yu, Keke
    Han, Baohui
    JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 2018, 156 (05) : 2006 - +
  • [23] Adjuvant chemoradiation versus chemotherapy for stage III gastric cancer after surgery with curative intent
    Turanli, Sevim
    Atalay, Can
    Berberoglu, Ugur
    Gulben, Kaptan
    JOURNAL OF CANCER RESEARCH AND THERAPEUTICS, 2015, 11 (02) : 369 - 374
  • [24] Asialoglycoprotein Receptor 2 Expression in Patients With Locally Advanced Gastric Cancer After Curative Resection
    Oshima, Takashi
    Hashimoto, Itaru
    Hiroshima, Yukihiko
    Kimura, Yayoi
    Tanabe, Mie
    Onuma, Shizune
    Nagasawa, Shinsuke
    Kanematsu, Kyohei
    Aoyama, Toru
    Yamada, Takanobu
    Ogata, Takashi
    Rino, Yasushi
    Saito, Aya
    Miyagi, Yohei
    ANTICANCER RESEARCH, 2024, 44 (01) : 397 - 402
  • [25] The Effect of Helicobacter pylori on Gastric Cancer Treated with Adjuvant Chemotherapy After Curative Resection
    Turanli, Sevim
    Bozdogan, Nazan
    Mersin, Hakan
    Berberoglu, Ugur
    INDIAN JOURNAL OF SURGERY, 2015, 77 (06) : 489 - 494
  • [26] The patterns and timing of recurrence after curative resection for gastric cancer in China
    Liu, Dan
    Lu, Ming
    Li, Jian
    Yang, Zuyao
    Feng, Qi
    Zhou, Menglong
    Zhang, Zhen
    Shen, Lin
    WORLD JOURNAL OF SURGICAL ONCOLOGY, 2016, 14
  • [27] The Effect of Helicobacter pylori on Gastric Cancer Treated with Adjuvant Chemotherapy After Curative Resection
    Sevim Turanli
    Nazan Bozdogan
    Hakan Mersin
    Ugur Berberoglu
    Indian Journal of Surgery, 2015, 77 : 489 - 494
  • [28] The impact of delayed adjuvant chemotherapy on survival in gastric cancer patients with and without preoperative chemotherapy
    Shimonosono, Masataka
    Arigami, Takaaki
    Matsushita, Daisuke
    Tsuruda, Yusuke
    Sasaki, Ken
    Baba, Kenji
    Ohtsuka, Takao
    ANNALS OF GASTROENTEROLOGICAL SURGERY, 2025,
  • [29] Negative Impact of Leakage on Survival of Patients Undergoing Curative Resection for Advanced Gastric Cancer
    Yoo, Han Mo
    Lee, Han Hong
    Shim, Jung Ho
    Jeon, Hae Myung
    Park, Cho Hyun
    Song, Kyo Young
    JOURNAL OF SURGICAL ONCOLOGY, 2011, 104 (07) : 734 - 740
  • [30] High-risk characteristics of pathological stage I lung adenocarcinoma after resection: patients for whom adjuvant chemotherapy should be performed
    Wu, Lei-Lei
    Jiang, Wen-Mei
    Qian, Jia-Yi
    Tian, Jia-Yuan
    Li, Zhi-Xin
    Li, Kun
    Ma, Guo-Wei
    Xie, Dong
    Chen, Chang
    HELIYON, 2023, 9 (12)