Research Advance of Chinese Medicine in Treating Atherosclerosis: Focus on Lipoprotein-Associated Phospholipase A2

被引：2
|
作者：
Wang, Lu-ming [1 ]
Zhang, Wen-lan [1 ]
Lyu, Nuan [1 ]
Suo, Yan-rong [2 ]
Yang, Lin [1 ]
Yu, Bin [3 ]
Jiang, Xi-juan [1 ]
机构：
[1] Tianjin Univ Tradit Chinese Med, Sch Integrat Med, Tianjin 301617, Peoples R China
[2] Ganzhou Peoples Hosp, Dept Tradit Chinese Med, Ganzhou 341000, Jiangxi, Peoples R China
[3] Tianjin Univ Tradit Chinese Med, Sch Med Technol, Tianjin 301617, Peoples R China
来源：
CHINESE JOURNAL OF INTEGRATIVE MEDICINE | 2024年 / 30卷 / 03期
基金：
中国国家自然科学基金;
关键词：
lipoprotein-associated phospholipase A2; atherosclerosis; inflammation; oxidative stress; apoptosis; Chinese medicine; PLATELET-ACTIVATING-FACTOR; OXYGEN SPECIES PRODUCTION; RHO-KINASE; MACROPHAGE APOPTOSIS; A(2) EXPRESSION; LYSOPHOSPHATIDYLCHOLINE; RESVERATROL; INFLAMMATION; INHIBITION; LP-PLA(2);
D O I：
10.1007/s11655-023-3611-6
中图分类号：
R [医药、卫生];
学科分类号：
10 ;
摘要：
As a serious cardiovascular disease, atherosclerosis (AS) causes chronic inflammation and oxidative stress in the body and poses a threat to human health. Lipoprotein-associated phospholipase A2 (Lp-PLA2) is a member of the phospholipase A2 (PLA2) family, and its elevated levels have been shown to contribute to AS. Lp-PLA2 is closely related to a variety of lipoproteins, and its role in promoting inflammatory responses and oxidative stress in AS is mainly achieved by hydrolyzing oxidized phosphatidylcholine (oxPC) to produce lysophosphatidylcholine (lysoPC). Moreover, macrophage apoptosis within plaque is promoted by localized Lp-PLA2 which also promotes plaque instability. This paper reviews those researches of Chinese medicine in treating AS via reducing Lp-PLA2 levels to guide future experimental studies and clinical applications related to AS.
引用
收藏
页码：277 / 288
页数：12
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