Neohesperidin Dihydrochalcone Improves Hyperglycemia and Insulin Resistance in Diabetic Zebrafish

被引：4
作者：
Tao, Fuying [1 ,2 ]
Wang, Pei [1 ,2 ]
Dai, Ziru [1 ,2 ]
Zhang, Chenxiao [1 ,2 ]
Li, Dongliang [3 ]
Fan, Heliang [1 ,2 ]
Qin, Mei [1 ,2 ]
Qi, Cen [1 ,2 ]
Hao, Junguang [1 ,2 ]
机构：
[1] Guangxi Univ, Guangxi Coll, Nanning 530004, Peoples R China
[2] Guangxi Univ, Univ Key Lab High Value Utilizat Seafood & Prepare, Coll Light Ind & Food Engn, Nanning 530004, Peoples R China
[3] East China Normal Univ, Sch Life Sci, Lab Aquaculture Nutr & Environm Hlth LANEH, Shanghai 200241, Peoples R China
来源：
ACS FOOD SCIENCE & TECHNOLOGY | 2023年 / 3卷 / 09期
关键词：
neohesperidin dihydrochalcone; improve; diabeticzebrafish; hyperglycemia; insulin resistance; dietary supplement; C-REACTIVE PROTEIN; SKELETAL-MUSCLE; INTERLEUKIN-6; INHIBITION; METABOLISM; FLAVONOIDS; REGENERATION; DYSFUNCTION; EXPRESSION; PANCREAS;
D O I：
10.1021/acsfoodscitech.3c00200
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
Neohesperidin dihydrochalcone (NHDC), a bicyclic flavonoidcompound,has many important physiological functions. However, the underlyinghypoglycemic mechanism of NHDC is not clear. We investigated the mechanismunderlying the antihyperglycemic effects of NHDC by cloning diabeticzebrafish. NHDC (0.5 mg/mL) substantially alleviated hyperglycemiaand hyperinsulinemia in diabetic zebrafish, reduced fasting bloodglucose, glycated serum protein, serum glucose, triacylglycerol, cholesterol,and insulin levels and HOMA-IR, TNF-& alpha;, IL-6, G6P, and PEPCKactivities, and increased GCK activity. Histological examination ofhepatic tissues showed that NHDC substantially reduced diabetes-exacerbatedlipid accumulation in liver tissues. Transcriptomic and polymerasechain reaction analyses indicated that NHDC improves insulin resistancepossibly by activating the insulin pathway (PI3K/AKT) and regulatingglucolipid metabolism and inflammatory responses. This study demonstratedthe anti-insulin resistance properties of NHDC and its effect on hyperglycemiaand hypolipidemia, providing new insights into the antidiabetic effectsof NHDC and its use as a dietary supplement for diabetic therapy.
引用
收藏
页码：1548 / 1558
页数：11
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