Failure of mobilization of hematopoietic stem cells associated with elevated serum levels of anti-CD38 monoclonal antibody

被引：7
|
作者：
Seth, Abhishek [1 ]
Murray, David [2 ]
Buadi, Francis K. [1 ]
Gertz, Morie A. [1 ]
Yadav, Udit [1 ]
Kumar, Shaji K. [1 ]
Gonsalves, Wilson I. [1 ]
机构：
[1] Mayo Clin, Dept Hematol, 200 First St SW, Rochester, MN 55905 USA
[2] Mayo Clin, Dept Lab Med & Pathol, Rochester, MN 55905 USA
来源：
EUROPEAN JOURNAL OF HAEMATOLOGY | 2023年 / 111卷 / 02期
基金：
美国国家卫生研究院;
关键词：
daratumumab; impaired mobilization; mass-spectrometry; multiple myeloma; MULTIPLE-MYELOMA;
D O I：
10.1111/ejh.14008
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Daratumumab is an anti-CD38 antibody that is increasingly incorporated in induction regimens for treating patients with newly diagnosed multiple myeloma (NDMM). Previous reports have demonstrated a lower yield of hematopoietic stem cells (HSCs) after induction with daratumumab; however, none of them reported a failure to collect an adequate number of HSCs. We describe a case of adequate HSC mobilization failure in a patient who inadvertently received excessive doses of daratumumab and was confirmed by higher-than-expected circulating levels of daratumumab by mass spectrometry. Eventual clearance of circulating daratumumab was associated with the successful mobilization and harvesting of HSCs.
引用
收藏
页码：318 / 321
页数：4
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