Failure of mobilization of hematopoietic stem cells associated with elevated serum levels of anti-CD38 monoclonal antibody

被引：7
|
作者：
Seth, Abhishek [1 ]
Murray, David [2 ]
Buadi, Francis K. [1 ]
Gertz, Morie A. [1 ]
Yadav, Udit [1 ]
Kumar, Shaji K. [1 ]
Gonsalves, Wilson I. [1 ]
机构：
[1] Mayo Clin, Dept Hematol, 200 First St SW, Rochester, MN 55905 USA
[2] Mayo Clin, Dept Lab Med & Pathol, Rochester, MN 55905 USA
来源：
EUROPEAN JOURNAL OF HAEMATOLOGY | 2023年 / 111卷 / 02期
基金：
美国国家卫生研究院;
关键词：
daratumumab; impaired mobilization; mass-spectrometry; multiple myeloma; MULTIPLE-MYELOMA;
D O I：
10.1111/ejh.14008
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Daratumumab is an anti-CD38 antibody that is increasingly incorporated in induction regimens for treating patients with newly diagnosed multiple myeloma (NDMM). Previous reports have demonstrated a lower yield of hematopoietic stem cells (HSCs) after induction with daratumumab; however, none of them reported a failure to collect an adequate number of HSCs. We describe a case of adequate HSC mobilization failure in a patient who inadvertently received excessive doses of daratumumab and was confirmed by higher-than-expected circulating levels of daratumumab by mass spectrometry. Eventual clearance of circulating daratumumab was associated with the successful mobilization and harvesting of HSCs.
引用
收藏
页码：318 / 321
页数：4
相关论文
共 50 条
  • [31] Critical Analysis on the Mechanism of Action (MoA) of the Anti-CD38 Monoclonal Antibody Isatuximab in Multiple Myeloma (MM)
    Moreno, Laura
    Zabaleta, Aintzane
    Alignani, Diego
    Ajona, Daniel
    Lasa, Marta
    Maiso, Patricia
    Jelinek, Tomas
    Segura, Victor
    Delgado, Jose Antonio
    Rodriguez-Otero, Paula
    Prosper, Felipe
    San Miguel, Jesus
    Paiva, Bruno
    BLOOD, 2016, 128 (22)
  • [32] SAR650984, a humanized anti-CD38 antibody potently modulates intracellular and extracellular nucleotide levels of cancer cells
    Zhang, Bailin
    Yang, Guang
    Dai, Shujia
    He, Tim
    Simard, Daniel
    Song, Zhili
    Licht, Stuart
    Adrian, Francisco
    Cheng, Hong
    Cai, Ti
    CANCER RESEARCH, 2014, 74 (19)
  • [33] Daratumumab, a Novel Potent Human Anti-CD38 Monoclonal Antibody, Induces Significant Killing of Human Multiple Myeloma Cells: Therapeutic Implication
    Tai, Yu-Tzu
    de Weers, Michel
    Li, Xian-Feng
    Song, Weihua
    Nahar, Sabikun
    Bakker, Joost M.
    Vink, Tom
    Jacobs, Danielle
    Oomen, Lukas
    Bleeker, Wim K.
    Munshi, Nikhil C.
    van de Winkel, Jan G. J.
    Parren, Paul W. H. I.
    Richardson, Paul
    Anderson, Kenneth C.
    BLOOD, 2009, 114 (22) : 252 - 252
  • [34] Selection, Expansion, and Unique Pretreatment of Allogeneic Human Natural Killer Cells with Anti-CD38 Monoclonal Antibody for Efficient Multiple Myeloma Treatment
    Motais, Benjamin
    Charvatova, Sandra
    Walek, Zuzana
    Hrdinka, Matous
    Smolarczyk, Ryszard
    Cichon, Tomasz
    Czapla, Justyna
    Giebel, Sebastian
    Simicek, Michal
    Jelinek, Tomas
    Sevcikova, Tereza
    Sobotka, Jiri
    Koristek, Zdenek
    Hajek, Roman
    Bago, Juli R.
    CELLS, 2021, 10 (05)
  • [35] Pre-Clinical Efficacy of the Anti-CD38 Monoclonal Antibody (mAb) Isatuximab in Acute Myeloid Leukemia (AML)
    Jelinek, Tomas
    Zabaleta, Aintzane
    Perez, Cristina
    Ajona, Daniel
    Alignani, Diego
    Rodriguez, Idoia
    Garate, Sonia
    Sarvide, Sarai
    Lasa, Marta
    Maiso, Patricia
    Prosper, Felipe
    Hajek, Roman
    San Miguel, Jesus F.
    Paiva, Bruno
    BLOOD, 2017, 130
  • [36] MECHANISM OF ACTION (MOA) OF THE ANTI-CD38 MONOCLONAL ANTIBODY ISATUXIMAB IN ELDERLY PATIENTS WITH ACUTE MYELOID LEUKEMIA (AML)
    Zabaleta, Aintzane
    Jelinek, Tomas
    Simoes, Catia
    Perez, Cristina
    Prosper, Felipe
    Martinez-Cuadron, D.
    Bergua, J. M.
    Vives, S.
    Algarra, L.
    Tormo, M.
    Martinez, P.
    Serrano, J.
    Herrera, P.
    Ramos, F.
    Salamero, O.
    Lavilla, E.
    Sanz, M. A.
    Montesinos, P.
    San Miguel, J. F.
    Paiva, Bruno
    HAEMATOLOGICA, 2020, 105 : 60 - 60
  • [37] Resistance of human hematopoietic stem cells to a monoclonal antibody recognizing CD43
    Bazil, V
    Brandt, JE
    Hoffman, R
    STEM CELLS, 1997, 15 : 13 - 18
  • [38] Single Center Real World Data That Compares Autologous Stem Cell Transplant in the Era of Anti-CD38 Monoclonal Antibody Based Treatments for AL Amyloidosis
    Yilmaz, Hulya
    Cengiz, Guldane
    Karakaya, Bulent
    Yavuz, Gul
    Aydogan, Merve
    Bozdag, Sinem Civriz
    Toprak, Selami Kocak
    Yuksel, Meltem Kurt
    Topcuoglu, Pervin
    Arslan, Onder
    Ozcan, Muhit
    Ilhan, Osman
    Beksac, Meral
    BLOOD, 2022, 140 : 4369 - 4370
  • [39] A Brief Report on Pre-Transfusion Testing in Patients Receiving the Anti-CD38 Monoclonal Antibody for Hematological Disorders in India
    Biswas, Durba
    Basu, Debapriya
    Nag, Arijit
    Kumar, Jeevan
    Datta, Suvro Sankha
    INDIAN JOURNAL OF HEMATOLOGY AND BLOOD TRANSFUSION, 2024, 40 (04) : 728 - 729
  • [40] Anti-CD38 monoclonal antibody interference with blood compatibility testing: Differentiating isatuximab and daratumumab via functional epitope mapping
    Chami, Btissam
    Okuda, Makoto
    Moayeri, Morvarid
    Pirenne, France
    Hidaka, Yoko
    Nambiar, Ashok
    Song, Zhili
    Bedel, Olivier
    Zhang, Bailin
    Hopke, Joern
    Deng, Gejing
    Zhu, Chen
    Mace, Sandrine
    Chiron, Marielle
    Adrian, Francisco
    Fukao, Taro
    Basile, Frank G.
    Martin, Thomas
    TRANSFUSION, 2022, 62 (11) : 2334 - 2348
12345