Modeling Nonalcoholic Fatty Liver Disease in the Dish Using Human-Specific Platforms: Strategies and Limitations

被引：11
|
作者：
Rezvani, Milad [1 ,2 ,3 ,4 ]
Vallier, Ludovic [3 ,5 ]
Guillot, Adrien [6 ,7 ,8 ,9 ]
机构：
[1] Charite Univ Med Berlin, Dept Pediat Gastroenterol Nephrol & Metab Med, Berlin, Germany
[2] Cincinnati Childrens Hosp Med Ctr, Div Gastroenterol Hepatol & Nutr, Cincinnati, OH USA
[3] Berlin Inst Hlth, Ctr Regenerat Therapies BCRT, Berlin, Germany
[4] Berlin Inst Hlth, Clinician Sci Program, Berlin, Germany
[5] Max Planck Inst Mol Genet, Berlin, Germany
[6] Charite Univ Med Berlin, Campus Virchow Klinikum, Berlin, Germany
[7] Campus Charite Mitte, Dept Hepatol & Gastroenterol, Berlin, Germany
[8] Charite Univ Med Berlin, Campus Virchow Klinikum, D-13353 Berlin, Germany
[9] Campus Charite Mitte, Dept Hepatol & Gastroenterol, D-13353 Berlin, Germany
来源：
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY | 2023年 / 15卷 / 05期
关键词：
Induced Pluripotent Stem Cells; Liver-on-Chip; Precision-Cut Liver Slices; Liver Organoids; PLURIPOTENT STEM-CELLS; PRECISION-CUT LIVER; CHOLANGIOCYTE ORGANOIDS; GENE-EXPRESSION; HEPATOCYTES; GENERATION; METABOLISM; EPITHELIUM; SLICES; MOUSE;
D O I：
10.1016/j.jcmgh.2023.01.014
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
This review article presents the latest research on nonal-coholic fatty liver disease (NAFLD) in vitro modeling. Ben-efits and limitations of using human induced pluripotent stem cell-derived approaches, primary organoids, liver-on-a-chip, and precision-cut liver sections are discussed to help researchers choose the most appropriate model.
引用
收藏
页码：1135 / 1145
页数：11
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