High expression of TARS is associated with poor prognosis of endometrial cancer

被引：0
作者：
Si, Lihui [1 ]
Liu, Lianchang [2 ]
Yang, Ruiqi [3 ]
Li, Wenxin [1 ]
Xu, Xiaohong [1 ]
机构：
[1] Second Hosp Jilin Univ, Dept Obstet & Gynecol, Changchun 130021, Peoples R China
[2] Second Hosp Jilin Univ, Dept Intervent, Changchun 130021, Peoples R China
[3] Second Hosp Jilin Univ, Phys Examinat Ctr, Changchun 130021, Peoples R China
来源：
AGING-US | 2023年 / 15卷 / 05期
关键词：
TARS; overall survival; disease specific survival; endometrial cancer; biomarker; CARCINOMA; BIOMARKER; HE-4;
D O I：
暂无
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Introduction: Endometrial cancer is the second largest and most common cancer in the world. It is urgent to explore novel biomarkers.Methods: Data were obtained from The Cancer Genome Atlas (TCGA) database. The receiver operating characteristic (ROC) curves, Kaplan-Meier curves and Cox analysis, nomograms, gene set enrichment analysis (GSEA) were conducted. Cell proliferation experiments were performed in Ishikawa cell.Results: TARS was significantly highly expressed in serous type, G3 grade, and deceased status. Significant association was between high TARS expression with poor overall survival (P = 0.0012) and poor disease specific survival (P = 0.0034). Significant differences were observed in advanced stage, G3 and G4, and old. The stage, diabetes, histologic grade, and TARS expression showed independent prognostic value for overall survival of endometrial cancer. The stage, histologic grade, and TARS expression showed independent prognostic value for disease specific survival of endometrial cancer. Activated CD4+ T cell, effector memory CD4+ T cell, memory B cell and type 2 T helper cell may participate in the high TARS expression related immune response in endometrial cancer. The CCK-8 results showed significantly inhibited cell proliferation in si-TARS (P < 0.05) and promoted cell proliferation in O-TARS (P < 0.05), confirmed by the colony formation and live/dead staining.Conclusion: High TARS expression was found in endometrial cancer with prognostic and predictive value. This study will provide new biomarker TARS for diagnosis and prognosis of endometrial cancer.
引用
收藏
页码：33 / 33
页数：1
相关论文
共 37 条
[31]   The cancer genome [J].
Stratton, Michael R. ;
Campbell, Peter J. ;
Futreal, P. Andrew .
NATURE, 2009, 458 (7239) :719-724
[32]   Molecular Basis of Endometriosis and Endometrial Cancer: Current Knowledge and Future Perspectives [J].
Terzic, Milan ;
Aimagambetova, Gulzhanat ;
Kunz, Jeannette ;
Bapayeva, Gauri ;
Aitbayeva, Botagoz ;
Terzic, Sanja ;
Lagana, Antonio Simone .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 22 (17)
[33]   Clinical actionability of molecular targets in endometrial cancer [J].
Urick, Mary Ellen ;
Bell, Daphne W. .
NATURE REVIEWS CANCER, 2019, 19 (09) :510-521
[34]   Incorporation of molecular characteristics into endometrial cancer management [J].
Vermij, Lisa ;
Smit, Vincent ;
Nout, Remi ;
Bosse, Tjalling .
HISTOPATHOLOGY, 2020, 76 (01) :52-63
[35]   The G protein-coupled receptor GPR30 mediates the proliferative effects induced by 17β-estradiol and hydroxytamoxifen in endometrial cancer cells [J].
Vivacqua, A ;
Bonofiglio, D ;
Recchia, AG ;
Musti, AM ;
Picard, D ;
Andò, S ;
Maggiolini, M .
MOLECULAR ENDOCRINOLOGY, 2006, 20 (03) :631-646
[36]   Integrated analysis of tumor mutation burden and immune infiltrates in endometrial cancer [J].
Zhou, Hongyu ;
Chen, Lihua ;
Lei, Yajie ;
Li, Tianjiao ;
Li, Haoran ;
Cheng, Xi .
CURRENT PROBLEMS IN CANCER, 2021, 45 (02)
[37]   Plasma-derived exosomal miR-15a-5p as a promising diagnostic biomarker for early detection of endometrial carcinoma [J].
Zhou, Lanyun ;
Wang, Wei ;
Wang, Fenfen ;
Yang, Siqi ;
Hu, Jiaqi ;
Lu, Bingjian ;
Pan, Zimin ;
Ma, Yu ;
Zheng, Mengyue ;
Zhou, Liyuan ;
Lei, Shufeng ;
Song, Penghong ;
Liu, Pengyuan ;
Lu, Weiguo ;
Lu, Yan .
MOLECULAR CANCER, 2021, 20 (01)
1234