The Role of NK Cells and Their Exosomes in Graft Versus Host Disease and Graft Versus Leukemia

被引：11
|
作者：
Zafarani, Alireza [1 ]
Taghavi-Farahabadi, Mahsa [2 ]
Razizadeh, Mohammad Hossein [3 ]
Amirzargar, Mohammad Reza [1 ]
Mansouri, Mansoure [4 ]
Mahmoudi, Mohammad [5 ]
机构：
[1] Iran Univ Med Sci, Fac Allied Med, Dept Hematol & Blood Banking, Tehran, Iran
[2] Univ Tehran Med Sci, Sch Med, Dept Immunol, Tehran, Iran
[3] Iran Univ Med Sci, Fac Med, Dept Virol, Tehran, Iran
[4] Shahid Beheshti Univ Med Sci, Sch Med, Dept Immunol, Tehran, Iran
[5] Iran Univ Med Sci, Sch Med, Dept Immunol, Tehran, Iran
来源：
STEM CELL REVIEWS AND REPORTS | 2023年 / 19卷 / 01期
关键词：
NK cell; Exosomes; GVHD; GVL; Hematopoietic stem cell transplantation; Cytomegalovirus; NATURAL-KILLER-CELLS; MHC CLASS-I; KIR LIGAND INCOMPATIBILITY; EXPRESSING INHIBITORY KIR; ACUTE MYELOID-LEUKEMIA; T-CELL; MISSING-SELF; HAPLOIDENTICAL HSCT; INTERFERON-GAMMA; ACUTE GVHD;
D O I：
10.1007/s12015-022-10449-2
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Natural killer (NK) cells are one of the innate immune cells that play an important role in preventing and controlling tumors and viral diseases, but their role in hematopoietic stem cell transplantation (HCT) is not yet fully understood. However, according to some research, these cells can prevent infections and tumor relapse without causing graft versus host disease (GVHD). In addition to NK cells, several studies are about the anti-leukemia effects of NK cell-derived exosomes that can highlight their roles in graft-versus-leukemia (GVL). In this paper, we intend to investigate the results of various articles on the role of NK cells in allogeneic hematopoietic cell transplantation and also their exosomes in GVL. Also, we have discussed the antiviral effects of these cells in post-HCT cytomegalovirus infection.
引用
收藏
页码：26 / 45
页数：20
相关论文
共 50 条
  • [41] Prevention of graft-versus-host-disease with preserved graft-versus-leukemia-effect by ex vivo and in vivo modulation of CD4+ T-cells
    Stephan Fricke
    Nadja Hilger
    Christian Fricke
    Uta Schönfelder
    Gerhard Behre
    Peter Ruschpler
    Andreas Boldt
    Christopher Oelkrug
    Ulrich Sack
    Frank Emmrich
    Cellular and Molecular Life Sciences, 2014, 71 : 2135 - 2148
  • [42] Prevention of graft-versus-host-disease with preserved graft-versus-leukemia-effect by ex vivo and in vivo modulation of CD4+ T-cells
    Fricke, Stephan
    Hilger, Nadja
    Fricke, Christian
    Schoenfelder, Uta
    Behre, Gerhard
    Ruschpler, Peter
    Boldt, Andreas
    Oelkrug, Christopher
    Sack, Ulrich
    Emmrich, Frank
    CELLULAR AND MOLECULAR LIFE SCIENCES, 2014, 71 (11) : 2135 - 2148
  • [43] Adult adherent stromal cells in the management of graft-versus-host disease
    Newell, Laura F.
    Deans, Robert J.
    Maziarz, Richard T.
    EXPERT OPINION ON BIOLOGICAL THERAPY, 2014, 14 (02) : 231 - 246
  • [44] Effects of regulatory dendritic cells on graft-versus-host disease and graft-versus-leukemia in mice after allogeneic bone marrow transplantation
    Yue, Xiao-Tong
    Wei, Xin-Xin
    Jia, Wen-Hua
    Mao, Hui
    Chen, Wan-Ru
    Gu, Hong-Hong
    Wu, Jia-Qing
    Li, De-Peng
    Xu, Kai-Lin
    Huang, Yi-Hong
    INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, 2018, 11 (08): : 7800 - 7810
  • [45] The Role of Myeloid-Derived Suppressor Cells (MDSCs) in Graft-versus-Host Disease (GVHD)
    Demosthenous, Christos
    Sakellari, Ioanna
    Douka, Vassiliki
    Papayanni, Penelope Georgia
    Anagnostopoulos, Achilles
    Gavriilaki, Eleni
    JOURNAL OF CLINICAL MEDICINE, 2021, 10 (10)
  • [46] Natural Killer Cells in Allogeneic Transplantation: Effect on Engraftment, Graft- versus-Tumor, and Graft-versus-Host Responses
    Gill, Saar
    Olson, Janelle A.
    Negrin, Robert S.
    BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2009, 15 (07) : 765 - 776
  • [47] Preferential usage of T cell receptor (TCR) V β by allogeneic T cells recognizing myeloid leukemia cells: implications for separating graft-versus-leukemia effect from graft-versus-host disease
    Y-Z Jiang
    DA Mavroudis
    S Dermime
    J Molldrem
    NF Hensel
    AJ Barrett
    Bone Marrow Transplantation, 1997, 19 : 899 - 903
  • [48] Cutaneous graft-versus-host disease
    Cho, A.
    Just, U.
    Knobler, R.
    HAUTARZT, 2018, 69 (02): : 109 - 115
  • [49] Acute graft-versus-host disease
    Malard, Florent
    Holler, Ernst
    Sandmaier, Brenda M.
    Huang, He
    Mohty, Mohamad
    NATURE REVIEWS DISEASE PRIMERS, 2023, 9 (01)
  • [50] Graft-versus-host disease management
    Mistrik, M.
    Bojtarova, E.
    Sopko, L.
    Masakova, L.
    Roziakova, L.
    Martinka, J.
    Batorova, A.
    BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY, 2016, 117 (07): : 388 - 396
12345