The Role of NK Cells and Their Exosomes in Graft Versus Host Disease and Graft Versus Leukemia

被引：11

作者：

Zafarani, Alireza ^{[1
]}

Taghavi-Farahabadi, Mahsa ^{[2
]}

Razizadeh, Mohammad Hossein ^{[3
]}

Amirzargar, Mohammad Reza ^{[1
]}

Mansouri, Mansoure ^{[4
]}

Mahmoudi, Mohammad ^{[5
]}

机构：

[1] Iran Univ Med Sci, Fac Allied Med, Dept Hematol & Blood Banking, Tehran, Iran

[2] Univ Tehran Med Sci, Sch Med, Dept Immunol, Tehran, Iran

[3] Iran Univ Med Sci, Fac Med, Dept Virol, Tehran, Iran

[4] Shahid Beheshti Univ Med Sci, Sch Med, Dept Immunol, Tehran, Iran

[5] Iran Univ Med Sci, Sch Med, Dept Immunol, Tehran, Iran

来源：

STEM CELL REVIEWS AND REPORTS | 2023年 / 19卷 / 01期

关键词：

NK cell; Exosomes; GVHD; GVL; Hematopoietic stem cell transplantation; Cytomegalovirus; NATURAL-KILLER-CELLS; MHC CLASS-I; KIR LIGAND INCOMPATIBILITY; EXPRESSING INHIBITORY KIR; ACUTE MYELOID-LEUKEMIA; T-CELL; MISSING-SELF; HAPLOIDENTICAL HSCT; INTERFERON-GAMMA; ACUTE GVHD;

D O I：

10.1007/s12015-022-10449-2

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Natural killer (NK) cells are one of the innate immune cells that play an important role in preventing and controlling tumors and viral diseases, but their role in hematopoietic stem cell transplantation (HCT) is not yet fully understood. However, according to some research, these cells can prevent infections and tumor relapse without causing graft versus host disease (GVHD). In addition to NK cells, several studies are about the anti-leukemia effects of NK cell-derived exosomes that can highlight their roles in graft-versus-leukemia (GVL). In this paper, we intend to investigate the results of various articles on the role of NK cells in allogeneic hematopoietic cell transplantation and also their exosomes in GVL. Also, we have discussed the antiviral effects of these cells in post-HCT cytomegalovirus infection.

引用

页码：26 / 45

页数：20

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