The role of dendritic cells in cancer immunity and therapeutic strategies

被引：7

作者：

Tai, Yunze ^{[1
]}

Chen, Man ^{[2
]}

Wang, Fang ^{[3
]}

Fan, Yu ^{[4
,5
]}

Zhang, Junlong ^{[1
]}

Cai, Bei ^{[1
]}

Yan, Lin ^{[1
]}

Luo, Yao ^{[1
]}

Li, Yi ^{[1
]}

机构：

[1] Sichuan Univ, West China Hosp, Dept Lab Med, Chengdu 610041, Peoples R China

[2] Hebei Yanda Lu Daopei Hosp, Langfang 065201, Peoples R China

[3] Guizhou Med Univ, Affiliated Hosp 2, Dept Med Lab, Kaili 556000, Guizhou, Peoples R China

[4] Sichuan Univ, West China Hosp, Natl Clin Res Ctr Geriatr, Dept Urol, 37 Guoxue Xiang, Chengdu 610041, Peoples R China

[5] Sichuan Univ, West China Hosp, Organ Transplantat Ctr, 37 Guoxue Xiang, Chengdu, Peoples R China

来源：

INTERNATIONAL IMMUNOPHARMACOLOGY | 2024年 / 128卷

关键词：

Dendritic cells; Cancer; Tumor microenvironment; Immunotherapy; Nanotherapy; Vaccines; ENDOTHELIAL GROWTH-FACTOR; CROSS-PRESENTATION; T-CELLS; ANTITUMOR IMMUNITY; SIPULEUCEL-T; FLT3; LIGAND; DC SUBSET; NK CELLS; PHASE-II; ANTIGEN;

D O I：

10.1016/j.intimp.2024.111548

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Dendritic cells (DCs) are asserted as the most potent antigen-presenting cells (APCs) that orchestrate both innate and adaptive immunity, being extremely effective in the induction of robust anti-cancer T cell responses. Hence, the modulation of DCs function represents an attractive target for improving cancer immunotherapy efficacy. A better understanding of the immunobiology of DCs, the interaction among DCs, immune effector cells and tumor cells in tumor microenvironment (TME) and the latest advances in biomedical engineering technology would be required for the design of optimal DC-based immunotherapy. In this review, we focus on elaborating the immunobiology of DCs in healthy and cancer environments, the recent advances in the development of enhancing endogenous DCs immunocompetence via immunomodulators as well as DC-based vaccines. The rapidly developing field of applying nanotechnology to improve DC-based immunotherapy is also highlighted.

引用

页数：17

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