Efficient and Facile One-Pot Multi-Component Synthesis of Betti Bases Using Baker's Yeast for the First Time

被引:1
作者
Kauser, Samreen [1 ]
Ullah, Qasim [1 ]
Rehman, Aram [1 ]
Khan, Salman Ahmad [1 ]
Mohammed, Arifuddin [2 ]
机构
[1] Maulana Azad Natl Urdu Univ MANUU, Sch Sci, Phys Sci Sect, Hyderabad 500032, Telangana, India
[2] Maulana Azad Natl Urdu Univ MANUU, Directorate Distance Educ, Hyderabad 500032, Telangana, India
关键词
Baker's yeast; green synthesis; multi-component reaction; betti reaction; 1-(alpha-aminoalkyl)-2-naphthols; SOLVENT-FREE; ORGANIC-SYNTHESIS; CATALYST; CHEMISTRY; NANOPARTICLES; DERIVATIVES; OXIDE; INHIBITORS;
D O I
10.1080/10406638.2023.2265022
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A green and facile synthesis of 1-(alpha-aminoalkyl)-2-naphthols, generally called Betti bases (BB) in the presence of Baker's yeast (BY), acts as an efficient catalyst, and ethanol as a green solvent. In this methodology, the BY is used first time as a biocatalyst (enzyme). This protocol has some inherent advantages, such as mild reaction conditions, no environmental pollution, simple work up, no need of column chromatography, diversity of reactant and desired 1-(alpha-aminoalkyl)-2-naphthols (Betti bases) (4a-r) are obtained in good-to-excellent yields. This is the first report on Baker's yeast-catalyzed (BYC) synthesis for BB. This present bio-catalytical route for synthesizing BB in the presence of biocatalysts like BY is anticipated to open a gateway to synthesized complexed biological active molecules counting BB.
引用
收藏
页码:5412 / 5423
页数:12
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