Sex-specific differences in primary Sjogren's disease

被引:4
作者
Punnanitinont, Achamaporn [1 ]
Kramer, Jill M. [1 ]
机构
[1] SUNY Buffalo, Sch Dent Med, Dept Oral Biol, Buffalo, NY 14222 USA
来源
FRONTIERS IN DENTAL MEDICINE | 2023年 / 4卷
关键词
X chromosome; estrogen; X chromosome inactivation (XCI); microbiome; salivary glands; BRUTONS TYROSINE KINASE; B-CELLS; PERIPHERAL-BLOOD; X-CHROMOSOME; T-CELLS; REGULATORY FACTOR; DENDRITIC CELLS; DEFICIENT MICE; RECEPTOR; EXPRESSION;
D O I
10.3389/fdmed.2023.1168645
中图分类号
R78 [口腔科学];
学科分类号
1003 ;
摘要
Many autoimmune diseases show a striking female sex predilection, including primary Sjogren's disease (pSD). Patients with pSD display exocrine gland pathology, such as salivary hypofunction and salivary and lacrimal gland inflammation. Moreover, many serious systemic disease manifestations are well-documented, including interstitial nephritis, hypergammaglobulinemia and neuropathies. Of note, women and men with pSD display distinct clinical phenotypes. While the underlying reasons for these clinical observations were poorly understood for many years, recent studies provide mechanistic insights into the specific regulatory landscapes that mediate female susceptibility to autoimmunity. We will review factors that contribute to the female sex bias, with an emphasis on those that are most relevant to pSD pathogenesis. Specifically, we will focus on sex hormones in disease, genetic alterations that likely contribute to the significant disease prevalence in females, and studies that provide evidence for the role of the gut microbiota in disease. Lastly, we will discuss therapeutics that are in clinical trials for pSD that may be particularly efficacious in targeting signaling networks that mediate inflammation in a sex-specific manner.
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页数:12
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