EWSR1::NR4A3 gene fusion in a cutaneous atypical myoepithelial neoplasm

被引：1

作者：

Scholl, Ashley Rose ^{[1
]}

Kliassov, Evelyna ^{[1
]}

Cardona, Diana M. ^{[1
]}

Bentley, Rex ^{[1
]}

Al-Rohil, Rami N. ^{[1
,2
,3
]}

机构：

[1] Duke Univ Hosp, Dept Pathol, Durham, NC USA

[2] Duke Univ Hosp, Dept Dermatol, Durham, NC USA

[3] Duke Univ, Med Ctr, Dept Pathol & Dermatol, Div Dermatopathol, 40 Duke Med Circle, Durham, NC 27710 USA

来源：

JOURNAL OF CUTANEOUS PATHOLOGY | 2023年 / 50卷 / 07期

关键词：

EWSR; myoepithelial carcinoma; soft tissue tumors; EXTRASKELETAL MYXOID CHONDROSARCOMA; SOFT-TISSUE; CARCINOMA; SPECTRUM;

D O I：

10.1111/cup.14429

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Myoepithelial neoplasms of the skin and soft tissue are rare and share histopathologic features with their salivary gland counterpart. We present a case of an atypical myoepithelial neoplasm from the back of a 72-year-old female. This lesion harbored an EWSR1::NR4A3 gene fusion, a genetic signature characteristically seen in extraskeletal myxoid chondrosarcoma. To our knowledge, this is a unique case of an atypical cutaneous myoepithelial neoplasm harboring EWSR1::NR4A3 fusion.

引用

页码：601 / 605

页数：5

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