EWSR1::NR4A3 gene fusion in a cutaneous atypical myoepithelial neoplasm

被引：1
|
作者：
Scholl, Ashley Rose [1 ]
Kliassov, Evelyna [1 ]
Cardona, Diana M. [1 ]
Bentley, Rex [1 ]
Al-Rohil, Rami N. [1 ,2 ,3 ]
机构：
[1] Duke Univ Hosp, Dept Pathol, Durham, NC USA
[2] Duke Univ Hosp, Dept Dermatol, Durham, NC USA
[3] Duke Univ, Med Ctr, Dept Pathol & Dermatol, Div Dermatopathol, 40 Duke Med Circle, Durham, NC 27710 USA
来源：
JOURNAL OF CUTANEOUS PATHOLOGY | 2023年 / 50卷 / 07期
关键词：
EWSR; myoepithelial carcinoma; soft tissue tumors; EXTRASKELETAL MYXOID CHONDROSARCOMA; SOFT-TISSUE; CARCINOMA; SPECTRUM;
D O I：
10.1111/cup.14429
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Myoepithelial neoplasms of the skin and soft tissue are rare and share histopathologic features with their salivary gland counterpart. We present a case of an atypical myoepithelial neoplasm from the back of a 72-year-old female. This lesion harbored an EWSR1::NR4A3 gene fusion, a genetic signature characteristically seen in extraskeletal myxoid chondrosarcoma. To our knowledge, this is a unique case of an atypical cutaneous myoepithelial neoplasm harboring EWSR1::NR4A3 fusion.
引用
收藏
页码：601 / 605
页数：5
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