Two new aryltetralin-type lignans from Camellia oleifera husk

被引：4

作者：

Cheng, Huai-yu ^{[1
]}

Xu, Tian-qi ^{[1
]}

Hu, Ya-lin ^{[1
]}

Shu, Qing ^{[1
]}

Xu, Wei ^{[1
]}

Fan, Chun-lin ^{[1
]}

Zhou, Guang-xiong ^{[1
]}

机构：

[1] Jinan Univ, Inst Tradit Chinese Med & Nat Prod, Coll Pharm, Guangdong Prov Key Lab Pharmacodynam Constituents, Guangzhou, Peoples R China

来源：

NATURAL PRODUCT RESEARCH | 2024年 / 38卷 / 13期

关键词：

Camellia oleifera; fruit husk; lignan; ECD; cytotoxicity; antioxidant activities; SASANQUASAPONIN; INHIBITION; ROOTS; SEEDS;

D O I：

10.1080/14786419.2023.2172005

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Two new aryltetralin-type lignans (1-2) were isolated from the dichloromethane fraction of 95% ethanol extract of Camellia oleifera fruit husk. Their structures were elucidated on the basis of spectroscopic analysis, and the absolute configurations of compounds 1-2 were determined by the comparison of measured ECD curves with the quantum chemical calculated ones. The new compounds were tested for their antioxidant activities and cytotoxicity against three human cancer cell lines (Huh-7, H460 and MCF-7). While compounds 1 and 2 only showed slight DPPH radical scavenging activities with the IC50 values of 38.68 +/- 5.02 and 56.62 +/- 1.49 mu M, respectively.

引用

页码：2264 / 2271

页数：8

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