Akkermansia muciniphila: a potential candidate for ameliorating metabolic diseases

被引：35
作者：
Niu, Huifang [1 ]
Zhou, Minfeng [2 ]
Zogona, Daniel [1 ]
Xing, Zheng [1 ]
Wu, Ting [1 ]
Chen, Rui [2 ]
Cui, Dandan [2 ]
Liang, Fengxia [3 ]
Xu, Xiaoyun [1 ]
机构：
[1] Huazhong Agr Univ, Minist Educ, Key Lab Environm Correlat Dietol, Sch Food Sci & Technol,Hubei Key Lab Fruit & Veget, Wuhan, Hubei, Peoples R China
[2] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Wuhan, Hubei, Peoples R China
[3] Hubei Univ Chinese Med, Sch Acupuncture & Bone Injury, Wuhan, Peoples R China
来源：
FRONTIERS IN IMMUNOLOGY | 2024年 / 15卷
关键词：
Akkermansia muciniphila; metabolic diseases; obesity; gut microbiota; health; GUT MICROBIOTA; WEIGHT-GAIN; FATTY-ACIDS; SP NOV; METFORMIN; INSULIN; PROBIOTICS; ABUNDANCE; GLUCOSE; LIVER;
D O I：
10.3389/fimmu.2024.1370658
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Metabolic diseases are comprehensive disease based on obesity. Numerous cumulative studies have shown a certain correlation between the fluctuating abundance of Akkermansia muciniphila and the occurrence of metabolic diseases. A. muciniphila, a potential probiotic candidate colonized in the human intestinal mucus layer, and its derivatives have various physiological functions, including treating metabolic disorders and maintaining human health. This review systematically explicates the abundance change rules of A. muciniphila in metabolic diseases. It also details the high efficacy and specific molecules mechanism of A. muciniphila and its derivatives in treating obesity, type 2 diabetes mellitus, cardiovascular disease, and non-alcoholic fatty liver disease.
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页数：13
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