Automatic covariance pattern analysis outperforms visual reading of 18F-fluorodeoxyglucose-positron emission tomography (FDG-PET) in variant progressive supranuclear palsy

被引:7
作者
Buchert, Ralph [1 ]
Wegner, Florian [2 ]
Huppertz, Hans-Juergen [3 ]
Berding, Georg [4 ]
Brendel, Matthias [5 ,6 ,7 ]
Apostolova, Ivayla [1 ]
Buhmann, Carsten [8 ]
Dierks, Alexander [9 ]
Katzdobler, Sabrina [6 ,7 ,10 ]
Klietz, Martin
Levin, Johannes [6 ,7 ,10 ]
Mahmoudi, Nima [11 ]
Rinscheid, Andreas [12 ]
Rogozinski, Sophia
Rumpf, Jost-Julian [13 ]
Schneider, Christine [14 ]
Stoecklein, Sophia [15 ]
Spetsieris, Phoebe G. [16 ]
Eidelberg, David [16 ]
Wattjes, Mike P.
Sabri, Osama [17 ]
Barthel, Henryk [17 ]
Hoeglinger, Guenter [2 ,6 ]
机构
[1] Univ Med Ctr Hamburg Eppendorf, Dept Diagnost & Intervent Radiol & Nucl Med, Hamburg, Germany
[2] Hannover Med Sch, Dept Neurol, Hannover, Germany
[3] Swiss Epilepsy Ctr, Zurich, Switzerland
[4] Hannover Med Sch, Dept Nucl Med, Hannover, Germany
[5] LMU, Univ Hosp Munich, Dept Nucl Med, Munich, Germany
[6] German Ctr Neurodegenerat Dis DZNE Munich, Munich, Germany
[7] Munich Cluster Syst Neurol SyNergy, Munich, Germany
[8] Univ Med Ctr Hamburg Eppendorf, Dept Neurol, Hamburg, Germany
[9] Univ Hosp Augsburg, Dept Nucl Med, Augsburg, Germany
[10] LMU, Univ Hosp Munich, Dept Neurol, Munich, Germany
[11] Hannover Med Sch, Dept Diagnost & Intervent Neuroradiol, Hannover, Germany
[12] Univ Hosp Augsburg, Med Phys & Radiat Protect, Augsburg, Germany
[13] Univ Leipzig, Dept Neurol, Leipzig, Germany
[14] Univ Hosp Augsburg, Dept Neurol & Clin Neurophysiol, Augsburg, Germany
[15] LMU, Univ Hosp Munich, Dept Radiol, Munich, Germany
[16] Feinstein Inst Med Res Manhasset, Manhasset, NY USA
[17] Univ Hosp Leipzig, Dept Nucl Med, Leipzig, Germany
基金
美国国家卫生研究院;
关键词
progressive supranuclear palsy; positron emission tomography; F-18-fluorodeoxyglucose; between-reader agreement; covariance pattern analysis; RICHARDSON-OLSZEWSKI SYNDROME; CEREBRAL GLUCOSE-METABOLISM; DIFFERENTIAL-DIAGNOSIS; PARKINSONS-DISEASE; POSITRON TOMOGRAPHY; BRAIN NETWORKS; BLOOD-FLOW; HYPOMETABOLISM; VALIDATION; DISORDERS;
D O I
10.1002/mds.29581
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background: To date, studies on positron emission tomography (PET) with F-18-fluorodeoxyglucose (FDG) in progressive supranuclear palsy (PSP) usually included PSP cohorts overrepresenting patients with Richardson's syndrome (PSP-RS). Objectives: To evaluate FDG-PET in a patient sample representing the broad phenotypic PSP spectrum typically encountered in routine clinical practice. Methods: This retrospective, multicenter study included 41 PSP patients, 21 (51%) with RS and 20 (49%) with non-RS variants of PSP (vPSP), and 46 age-matched healthy controls. Two state-of-the art methods for the interpretation of FDG-PET were compared: visual analysis supported by voxel-based statistical testing (five readers) and automatic covariance pattern analysis using a predefined PSP-related pattern. Results: Sensitivity and specificity of the majority visual read for the detection of PSP in the whole cohort were 74% and 72%, respectively. The percentage of false-negative cases was 10% in the PSP-RS subsample and 43% in the vPSP subsample. Automatic covariance pattern analysis provided sensitivity and specificity of 93% and 83% in the whole cohort. The percentage of false-negative cases was 0% in the PSP-RS subsample and 15% in the vPSP subsample. Conclusions: Visual interpretation of FDG-PET supported by voxel-based testing provides good accuracy for the detection of PSP-RS, but only fair sensitivity for vPSP. Automatic covariance pattern analysis outperforms visual interpretation in the detection of PSP-RS, provides clinically useful sensitivity for vPSP, and reduces the rate of false-positive findings. Thus, pattern expression analysis is clinically useful to complement visual reading and voxel-based testing of FDG-PET in suspected PSP. (C) 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
引用
收藏
页码:1901 / 1913
页数:13
相关论文
共 95 条
  • [1] Sensitivity and Specificity of Diagnostic Criteria for Progressive Supranuclear Palsy
    Ali, Farwa
    Martin, Peter R.
    Botha, Hugo
    Ahlskog, J. Eric
    Bower, James H.
    Masumoto, Joseph Y.
    Maraganore, Demetrius
    Hassan, Anhar
    Eggers, Scott
    Boeve, Bradley F.
    Knopman, David S.
    Drubach, Daniel
    Petersen, Ronald C.
    Dunkley, Erika Driver
    van Gerpen, Jay
    Uitti, Ryan
    Whitwell, Jennifer L.
    Dickson, Dennis W.
    Josephs, Keith A.
    [J]. MOVEMENT DISORDERS, 2019, 34 (08) : 1144 - 1153
  • [2] FDG PET in the differential diagnosis of degenerative parkinsonian disorders: usefulness of voxel-based analysis in clinical practice
    Arnone, Annachiara
    Allocca, Michela
    Di Dato, Rossella
    Puccini, Giulia
    Laghai, Iashar
    Rubino, Federica
    Nerattini, Matilde
    Ramat, Silvia
    Lombardi, Gemma
    Ferrari, Camilla
    Bessi, Valentina
    Sorbi, Sandro
    De Cristofaro, Maria Teresa
    Polito, Cristina
    Berti, Valentina
    [J]. NEUROLOGICAL SCIENCES, 2022, 43 (09) : 5333 - 5341
  • [3] PET/CT in diagnosis of movement disorders
    Berti, Valentina
    Pupi, Alberto
    Mosconi, Lisa
    [J]. PET/CT APPLICATIONS IN NON-NEOPLASTIC CONDITIONS, 2011, 1228 : 93 - 108
  • [4] POSITRON EMISSION TOMOGRAPHY STUDY IN PROGRESSIVE SUPRANUCLEAR PALSY - BRAIN HYPOMETABOLIC PATTERN AND CLINICOMETABOLIC CORRELATIONS
    BLIN, J
    BARON, JC
    DUBOIS, B
    PILLON, B
    CAMBON, H
    CAMBIER, J
    AGID, Y
    [J]. ARCHIVES OF NEUROLOGY, 1990, 47 (07) : 747 - 752
  • [5] Subcortical elevation of metabolism in Parkinson's disease - A critical reappraisal in the context of global mean normalization
    Borghammer, Per
    Cumming, Paul
    Aanerud, Joel
    Foerster, Stefan
    Gjedde, Albert
    [J]. NEUROIMAGE, 2009, 47 (04) : 1514 - 1521
  • [6] The pimple sign of progressive supranuclear palsy syndrome
    Botha, Hugo
    Whitwell, Jennifer L.
    Madhaven, Ajay
    Senjem, Matthew L.
    Lowe, Val
    Josephs, Keith A.
    [J]. PARKINSONISM & RELATED DISORDERS, 2014, 20 (02) : 180 - 185
  • [7] The utility of FDG-PET in the differential diagnosis of Parkinsonism
    Brajkovic, Leposava
    Kostic, Vladimir
    Sobic-Saranovic, Dragana
    Stefanova, Elka
    Jecmenica-Lukic, Milica
    Jesic, Ana
    Stojiljkovic, Milica
    Odalovic, Strahinja
    Gallivanone, Francesca
    Castiglioni, Isabella
    Radovic, Branislava
    Trajkovic, Goran
    Artiko, Vera
    [J]. NEUROLOGICAL RESEARCH, 2017, 39 (08) : 675 - 684
  • [8] Brooks DJ, 2016, HAND CLINIC, V135, P493, DOI 10.1016/B978-0-444-53485-9.00024-6
  • [9] Differential diagnosis of parkinsonism: a head-to-head comparison of FDG PET and MIBG scintigraphy
    Brumberg, Joachim
    Schroeter, Nils
    Blazhenets, Ganna
    Frings, Lars
    Volkmann, Jens
    Lapa, Constantin
    Jost, Wolfgang H.
    Isaias, Ioannis U.
    Meyer, Philipp T.
    [J]. NPJ PARKINSONS DISEASE, 2020, 6 (01)
  • [10] Adjusted scaling of FDG positron emission tomography images for statistical evaluation in patients with suspected Alzheimer's disease
    Buchert, R
    Wilke, F
    Chakrabarti, B
    Martin, B
    Brenner, W
    Mester, J
    Clausen, M
    [J]. JOURNAL OF NEUROIMAGING, 2005, 15 (04) : 348 - 355