Various strategies for developing APOBEC3G protectors to circumvent human immunodeficiency virus type 1

被引：0
作者：
Bao, Qiqi [1 ,2 ]
Zhou, Jinming [1 ,2 ]
机构：
[1] Zhejiang Normal Univ, Dept Chem, Key Lab Minist Educ Adv Catalysis Mat, 688 Yingbin Rd, Jinhua 321004, Peoples R China
[2] Zhejiang Normal Univ, Coll Chem & Life Sci, Drug Dev & Innovat Ctr, 688 Yingbin Rd, Jinhua 321004, Peoples R China
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2023年 / 250卷
关键词：
HIV-1; REVERSE-TRANSCRIPTASE; SMALL-MOLECULE INHIBITION; CYTIDINE DEAMINASE; MESSENGER-RNA; ANTIRETROVIRAL THERAPY; ANTIVIRAL ACTIVITY; CBF-BETA; INDEPENDENT RESTRICTION; ENZYME APOBEC3G; INNATE IMMUNITY;
D O I：
10.1016/j.ejmech.2023.115188
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Host restriction factor APOBEC3G (A3G) efficiently restricts Vif-deficient HIV-1 by being packaged with progeny virions and causing the G to A mutation during HIV-1 viral DNA synthesis as the progeny virus infects new cells. HIV-1 expresses Vif protein to resist the activity of A3G by mediating A3G degradation. This process requires the self-association of Vif in concert with A3G proteins, protein chaperones, and factors of the ubiquitination ma-chinery, which are potential targets to discover novel anti-HIV drugs. This review will describe compounds that have been reported so far to inhibit viral replication of HIV-1 by protecting A3G from Vif-mediated degradation.
引用
收藏
页数：14
相关论文
共 50 条
  • [31] APOBEC3G & HTLV-1: Inhibition without deamination
    Klaus Strebel
    [J]. Retrovirology, 2
  • [32] Analysis of Human APOBEC3H Haplotypes and Anti-Human Immunodeficiency Virus Type 1 Activity
    Wang, Xiaojun
    Abudu, Aierken
    Son, SungMo
    Dang, Ying
    Venta, Patrick J.
    Zheng, Yong-Hui
    [J]. JOURNAL OF VIROLOGY, 2011, 85 (07) : 3142 - 3152
  • [33] Regulation of vif mRNA Splicing by Human Immunodeficiency Virus Type 1 Requires 5′ Splice Site D2 and an Exonic Splicing Enhancer To Counteract Cellular Restriction Factor APOBEC3G
    Mandal, Dibyakanti
    Exline, Colin M.
    Feng, Zehua
    Stoltzfus, C. Martin
    [J]. JOURNAL OF VIROLOGY, 2009, 83 (12) : 6067 - 6078
  • [34] Prototype Foamy Virus Bet Impairs the Dimerization and Cytosolic Solubility of Human APOBEC3G
    Vasudevan, Ananda Ayyappan Jaguva
    Perkovic, Mario
    Bulliard, Yannick
    Cichutek, Klaus
    Trono, Didier
    Haeussinger, Dieter
    Muenk, Carsten
    [J]. JOURNAL OF VIROLOGY, 2013, 87 (16) : 9030 - 9040
  • [35] Regulation of APOBEC3 Proteins by a Novel YXXL Motif in Human Immunodeficiency Virus Type 1 Vif and Simian Immunodeficiency Virus SIVagm Vif
    Pery, Erez
    Rajendran, Kottampatty S.
    Brazier, Andrew Jay
    Gabuzda, Dana
    [J]. JOURNAL OF VIROLOGY, 2009, 83 (05) : 2374 - 2381
  • [36] Degradation-Independent Inhibition of APOBEC3G by the HIV-1 Vif Protein
    Stupfler, Benjamin
    Verriez, Cedric
    Gallois-Montbrun, Sarah
    Marquet, Roland
    Paillart, Jean-Christophe
    [J]. VIRUSES-BASEL, 2021, 13 (04):
  • [37] APOBEC3G and HIV-1: Strike and counterstrike
    Soros V.B.
    Greene W.C.
    [J]. Current Infectious Disease Reports, 2006, 8 (4) : 317 - 323
  • [38] APOBEC3G encapsidation into HIV-1 virions: which RNA is it?
    Klaus Strebel
    Mohammad A Khan
    [J]. Retrovirology, 5
  • [39] Encapsidation of APOBEC3G into HIV-1 virions involves lipid raft association and does not correlate with APOBEC3G oligomerization
    Khan, Mohammad A.
    Goila-Gaur, Ritu
    Kao, Sandra
    Miyagi, Eri
    Walker, Robert C., Jr.
    Strebel, Klaus
    [J]. RETROVIROLOGY, 2009, 6 : 99
  • [40] The structural basis for HIV-1 Vif antagonism of human APOBEC3G
    Li, Yen-Li
    Langley, Caroline A.
    Azumaya, Caleigh M.
    Echeverria, Ignacia
    Chesarino, Nicholas M.
    Emerman, Michael
    Cheng, Yifan
    Gross, John D.
    [J]. NATURE, 2023, 615 (7953) : 728 - +
12345