Various strategies for developing APOBEC3G protectors to circumvent human immunodeficiency virus type 1

被引：0
作者：
Bao, Qiqi [1 ,2 ]
Zhou, Jinming [1 ,2 ]
机构：
[1] Zhejiang Normal Univ, Dept Chem, Key Lab Minist Educ Adv Catalysis Mat, 688 Yingbin Rd, Jinhua 321004, Peoples R China
[2] Zhejiang Normal Univ, Coll Chem & Life Sci, Drug Dev & Innovat Ctr, 688 Yingbin Rd, Jinhua 321004, Peoples R China
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2023年 / 250卷
关键词：
HIV-1; REVERSE-TRANSCRIPTASE; SMALL-MOLECULE INHIBITION; CYTIDINE DEAMINASE; MESSENGER-RNA; ANTIRETROVIRAL THERAPY; ANTIVIRAL ACTIVITY; CBF-BETA; INDEPENDENT RESTRICTION; ENZYME APOBEC3G; INNATE IMMUNITY;
D O I：
10.1016/j.ejmech.2023.115188
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Host restriction factor APOBEC3G (A3G) efficiently restricts Vif-deficient HIV-1 by being packaged with progeny virions and causing the G to A mutation during HIV-1 viral DNA synthesis as the progeny virus infects new cells. HIV-1 expresses Vif protein to resist the activity of A3G by mediating A3G degradation. This process requires the self-association of Vif in concert with A3G proteins, protein chaperones, and factors of the ubiquitination ma-chinery, which are potential targets to discover novel anti-HIV drugs. This review will describe compounds that have been reported so far to inhibit viral replication of HIV-1 by protecting A3G from Vif-mediated degradation.
引用
收藏
页数：14
相关论文
共 50 条
  • [21] APOBEC3G/F as one possible driving force for co-receptor switch of the human immunodeficiency virus-1
    Eva Heger
    Alexander Thielen
    Ramona Gilles
    Martin Obermeier
    Thomas Lengauer
    Rolf Kaiser
    Susanna Trapp
    Medical Microbiology and Immunology, 2012, 201 : 7 - 16
  • [22] Identification of an HIV-1 replication inhibitor which rescues host restriction factor APOBEC3G in Vif-APOBEC3G complex
    Zhang, Shaoyang
    Zhong, Limei
    Chen, Bing
    Pan, Ting
    Zhang, Xue
    Liang, Liting
    Li, Qianwen
    Zhang, Ziying
    Chen, Hui
    Zhou, Jie
    Luo, Haihua
    Zhang, Hui
    Bai, Chuan
    ANTIVIRAL RESEARCH, 2015, 122 : 20 - 27
  • [23] Identification of a Novel HIV-1 Inhibitor Targeting Vif-dependent Degradation of Human APOBEC3G Protein
    Pery, Erez
    Sheehy, Ann
    Nebane, N. Miranda
    Brazier, Andrew Jay
    Misra, Vikas
    Rajendran, Kottampatty S.
    Buhrlage, Sara J.
    Mankowski, Marie K.
    Rasmussen, Lynn
    White, E. Lucile
    Ptak, Roger G.
    Gabuzda, Dana
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2015, 290 (16) : 10504 - 10517
  • [24] Expression of HIV-1 Vif and Human APOBEC3G with a Bicistronic Vector
    Yang Yishu
    Sun Xiaona
    Liu Di
    Wang Xiaoli
    Shen Sisi
    Li Zelin
    Zeng Yi
    MECHANICAL ENGINEERING AND MATERIALS SCIENCE, 2012, 108 : 141 - 145
  • [25] Contribution of APOBEC3G/F activity to the development of low-abundance drug-resistant human immunodeficiency virus type I variants
    Noguera-Julian, M.
    Cozzi-Lepri, A.
    Di Giallonardo, F.
    Schuurman, R.
    Daumer, M.
    Aitken, S.
    Ceccherini-Silberstein, F.
    Monforte, A. D'Arminio
    Geretti, A. M.
    Booth, C. L.
    Kaiser, R.
    Michalik, C.
    Jansen, K.
    Masquelier, B.
    Bellecave, P.
    Kouyos, R. D.
    Castro, E.
    Furrer, H.
    Schultze, A.
    Guenthard, H. F.
    Brun-Vezinet, F.
    Metzner, K. J.
    Paredes, R.
    CLINICAL MICROBIOLOGY AND INFECTION, 2016, 22 (02) : 191 - 200
  • [26] Positioning of APOBEC3G/F Mutational Hotspots in the Human Immunodeficiency Virus Genome Favors Reduced Recognition by CD8+ T Cells
    Monajemi, Mahdis
    Woodworth, Claire F.
    Zipperlen, Katrin
    Gallant, Maureen
    Grant, Michael D.
    Larijani, Mani
    PLOS ONE, 2014, 9 (04):
  • [27] Variability in HIV-1 transmitted/founder virus susceptibility to combined APOBEC3F and APOBEC3G host restriction
    Gaba, Amit
    Yousefi, Maria
    Bhattacharjee, Shreoshri
    Chelico, Linda
    JOURNAL OF VIROLOGY, 2025, 99 (01)
  • [28] Increased APOBEC3G and APOBEC3F expression is associated with low viral load and prolonged survival in simian immunodeficiency virus infected rhesus monkeys
    Mussil, Bianka
    Sauermann, Ulrike
    Motzkus, Dirk
    Stahl-Hennig, Christiane
    Sopper, Sieghart
    RETROVIROLOGY, 2011, 8
  • [29] APOBEC3G & HTLV-1: Inhibition without deamination
    Klaus Strebel
    Retrovirology, 2
  • [30] APOBEC3G Generates Nonsense Mutations in Human T-Cell Leukemia Virus Type 1 Proviral Genomes In Vivo
    Fan, Jun
    Ma, Guangyong
    Nosaka, Kisato
    Tanabe, Junko
    Satou, Yorifumi
    Koito, Atsushi
    Wain-Hobson, Simon
    Vartanian, Jean-Pierre
    Matsuoka, Masao
    JOURNAL OF VIROLOGY, 2010, 84 (14) : 7278 - 7287
12345