Extracellular vesicles in Alzheimer's disease: from pathology to therapeutic approaches

被引：22

作者：

Garcia-Contreras, Marta ^{[1
]}

Thakor, Avnesh S. ^{[1
]}

机构：

[1] Stanford Univ, Dept Radiol, Intervent Regenerat Med & Imaging Lab, Palo Alto, CA 94305 USA

来源：

NEURAL REGENERATION RESEARCH | 2023年 / 18卷 / 01期

关键词：

Alzheimer's disease; brain; diagnostic; extracellular vesicles; isolation methods; microglia; neurodegenerative diseases; neuroinflammation; neurons; therapy; MESENCHYMAL STEM-CELLS; EXOSOMES; PROTEINS; BRAIN; TAU; BIOMARKERS; MICROGLIA; MECHANISM; MODELS; DAMAGE;

D O I：

10.4103/1673-5374.343882

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Alzheimer's disease is a progressive and fatal neurodegenerative disorder that starts many years before the onset of cognitive symptoms. Identifying novel biomarkers for Alzheimer's disease has the potential for patient risk stratification, early diagnosis, and disease monitoring in response to therapy. A novel class of biomarkers is extracellular vesicles given their sensitivity and specificity to specific diseases. In addition, extracellular vesicles can be used as novel biological therapeutics given their ability to efficiently and functionally deliver therapeutic cargo. This is critical given the huge unmet need for novel treatment strategies for Alzheimer's disease. This review summarizes and discusses the most recent findings in this field.

引用

页码：18 / 22

页数：5

共 58 条

[1] Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes [J].

Alvarez-Erviti, Lydia ;

Seow, Yiqi ;

Yin, HaiFang ;

Betts, Corinne ;

Lakhal, Samira ;

Wood, Matthew J. A. .

NATURE BIOTECHNOLOGY, 2011, 29 (04) :341-U179

[2] Human neural stem cell-derived extracellular vesicles mitigate hallmarks of Alzheimer's disease [J].

Apodaca, Lauren A. ;

Baddour, Al Anoud D. ;

Garcia, Camilo, Jr. ;

Alikhani, Leila ;

Giedzinski, Erich ;

Ru, Ning ;

Agrawal, Anshu ;

Acharya, Munjal M. ;

Baulch, Janet E. .

ALZHEIMERS RESEARCH & THERAPY, 2021, 13 (01)

[3] Proteome profiling of neuron-derived exosomes in Alzheimer's disease reveals hemoglobin as a potential biomarker [J].

Arioz, Burak Ibrahim ;

Tufekci, Kemal Ugur ;

Olcum, Melis ;

Durur, Devrim Yagmur ;

Akarlar, Busra A. ;

Ozlu, Nurhan ;

Bagriyanik, H. Alper ;

Keskinoglu, Pembe ;

Yener, Gorsev ;

Genc, Sermin .

NEUROSCIENCE LETTERS, 2021, 755

[4] Depletion of microglia and inhibition of exosome synthesis halt tau propagation [J].

Asai, Hirohide ;

Ikezu, Seiko ;

Tsunoda, Satoshi ;

Medalla, Maria ;

Luebke, Jennifer ;

Haydar, Tank ;

Wolozin, Benjamin ;

Butovsky, Oleg ;

Kuegler, Sebastian ;

Ikezu, Tsuneya .

NATURE NEUROSCIENCE, 2015, 18 (11) :1584-1593

[5] A perspective on the isolation and characterization of extracellular vesicles from different biofluids [J].

Bano, Reshma ;

Ahmad, Farhan ;

Mohsin, Mohd .

RSC ADVANCES, 2021, 11 (32) :19598-19615

[6] High sensitivity detection of extracellular vesicles immunecaptured from urine by conventional flow cytometry [J].

Campos-Silva, Carmen ;

Suarez, Henar ;

Jara-Acevedo, Ricardo ;

Linares-Espinos, Estefania ;

Martinez-Pineiro, Luis ;

Yanez-Mo, Maria ;

Vales-Gomez, Mar .

SCIENTIFIC REPORTS, 2019, 9 (1)

[7] Isolation and characterization of extracellular vesicles from Broncho-alveolar lavage fluid: a review and comparison of different methods [J].

Carnino, Jonathan M. ;

Lee, Heedoo ;

Jin, Yang .

RESPIRATORY RESEARCH, 2019, 20 (01)

[8] miR-212 and miR-132 Are Downregulated in Neurally Derived Plasma Exosomes of Alzheimer's Patients [J].

Cha, Diana J. ;

Mengel, David ;

Mustapic, Maja ;

Liu, Wen ;

Selkoe, Dennis J. ;

Kapogiannis, Dimitrios ;

Galasko, Douglas ;

Rissman, Robert A. ;

Bennett, David A. ;

Walsh, Dominic M. .

FRONTIERS IN NEUROSCIENCE, 2019, 13

[9] Elucidation of Exosome Migration Across the Blood-Brain Barrier Model In Vitro [J].

Chen, Claire C. ;

Liu, Linan ;

Ma, Fengxia ;

Wong, Chi W. ;

Guo, Xuning E. ;

Chacko, Jenu V. ;

Farhoodi, Henry P. ;

Zhang, Shirley X. ;

Zimak, Jan ;

Segaliny, Aude ;

Riazifar, Milad ;

Pham, Victor ;

Digman, Michelle A. ;

Pone, Egest J. ;

Zhao, Weian .

CELLULAR AND MOLECULAR BIOENGINEERING, 2016, 9 (04) :509-529

[10] Mesenchymal Stem Cell-Derived Exosomes Ameliorate Alzheimer's Disease Pathology and Improve Cognitive Deficits [J].

Chen, Yi-An ;

Lu, Cheng-Hsiu ;

Ke, Chien-Chih ;

Chiu, Sain-Jhih ;

Jeng, Fong-Shya ;

Chang, Chi-Wei ;

Yang, Bang-Hung ;

Liu, Ren-Shyan .

BIOMEDICINES, 2021, 9 (06)

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