Novel therapeutic approaches for the management of hepatitis infections

被引:0
作者
Damodaran, Aswin [1 ]
Zachariah, Subin Mary [1 ]
Nair, Sreeja Chandrasekharan [1 ]
机构
[1] Amrita Vishwa Vidyapeetham, Amrita Sch Pharm, AIMS Hlth Sci Campus, Kochi 682041, Kerala, India
关键词
anti-viral therapy; drug delivery; Hepatitis B virus; nanotechnology; vaccine delivery; VIRUS-LIKE PARTICLES; B SURFACE-ANTIGEN; VACCINE DELIVERY; DRUG-DELIVERY; CHITOSAN NANOPARTICLES; IMMUNE-RESPONSES; GENE-THERAPY; IN-VITRO; T-CELL; MICROSPHERES;
D O I
10.4155/tde-2023-0074
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Hepatitis B virus (HBV) & hepatitis C virus (HCV) infection is a substantial reason for morbidity and mortality around the world. Chronic hepatitis B (CHB) infection is connected with an enhanced risk of liver cirrhosis, liver decompensation and hepatocellular carcinoma (HCC). Conventional therapy do face certain challenges, for example, poor tolerability and the growth of active resistance. Thus, novel treatment procedures are essential to accomplish the initiation of strong and stable antiviral immune reactions of the individuals. This review explores the current nanotechnology-based carriers for drug and vaccine delivery to treat HBV and HCV. Hepatitis infections are a major health problem that affects lots of people across the globe. Without treatment, it can seriously harm the liver and might even lead to a type of liver cancer. The treatments we currently have can sometimes cause side effects or the virus can learn how to fight back against them. This means we need new and better ways to treat it. In our article, we talk about how Hepatitis B and C affects the body and how our natural defenses try to protect us. We then dive into a kind of science called nanotechnology, which uses tiny particles to help deliver medicine or vaccines in a better way. This new method could help medications be better at treating Hepatitis B and C.
引用
收藏
页码:211 / 232
页数:22
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