Exploring Potential Epigenetic Biomarkers for Colorectal Cancer Metastasis

被引：13
作者：
Ajithkumar, Priyadarshana [1 ]
Vasantharajan, Sai Shyam [1 ]
Pattison, Sharon [2 ]
McCall, John L. [3 ]
Rodger, Euan J. [1 ]
Chatterjee, Aniruddha [1 ,4 ]
机构：
[1] Univ Otago, Dunedin Sch Med, Dept Pathol, Dunedin 9016, New Zealand
[2] Univ Otago, Dunedin Sch Med, Dept Med, Dunedin 9016, New Zealand
[3] Univ Otago, Dunedin Sch Med, Dept Surg Sci, Dunedin 9016, New Zealand
[4] UPES Univ, Sch Hlth Sci & Technol, Dehra Dun 248007, India
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2024年 / 25卷 / 02期
关键词：
colorectal cancer; DNA methylation; epigenetics; metastasis; lymph node; liver; histone modification; biomarkers; LYMPH-NODE METASTASIS; PROMOTER HYPERMETHYLATION; LYMPHOVASCULAR INVASION; PROGNOSTIC VALUE; POOR-PROGNOSIS; GENOME-WIDE; METHYLATION; EXPRESSION; PROLIFERATION; LANDSCAPE;
D O I：
10.3390/ijms25020874
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Metastatic progression is a complex, multistep process and the leading cause of cancer mortality. There is growing evidence that emphasises the significance of epigenetic modification, specifically DNA methylation and histone modifications, in influencing colorectal (CRC) metastasis. Epigenetic modifications influence the expression of genes involved in various cellular processes, including the pathways associated with metastasis. These modifications could contribute to metastatic progression by enhancing oncogenes and silencing tumour suppressor genes. Moreover, specific epigenetic alterations enable cancer cells to acquire invasive and metastatic characteristics by altering cell adhesion, migration, and invasion-related pathways. Exploring the involvement of DNA methylation and histone modification is crucial for identifying biomarkers that impact cancer prediction for metastasis in CRC. This review provides a summary of the potential epigenetic biomarkers associated with metastasis in CRC, particularly DNA methylation and histone modifications, and examines the pathways associated with these biomarkers.
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页数：18
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