Acute exacerbation of idiopathic pulmonary fibrosis after bivalent {tozinameran and famtozinameran} mRNA COVID-19 vaccination

被引:0
作者
Tsumura, Kenji [1 ]
Zaizen, Yoshiaki [1 ,2 ]
Umemoto, Shushi [1 ]
Tsuneyoshi, Shingo [1 ]
Matama, Goushi [1 ]
Okamoto, Masaki [1 ,3 ,4 ]
Tominaga, Masaki [1 ,5 ]
Hoshino, Tomoaki [1 ]
机构
[1] Kurume Univ, Dept Med, Div Respirol Neurol & Rheumatol, Sch Med, 67 Asahi Machi, Kurume, Fukuoka 8300011, Japan
[2] Nagasaki Univ, Dept Pathol Informat, Grad Sch Biomed Sci, 1-7-1 Sakamoto, Nagasaki 8528501, Japan
[3] Natl Hosp Org, Dept Respirol, Kyushu Med Ctr, 1-8-1 Jigyouhama,Chuo Ku, Fukuoka 8108563, Japan
[4] Natl Hosp Org, Clin Res Ctr, Kyushu Med Ctr, 1-8-1 Jigyouhama,Chuo Ku, Fukuoka 8108563, Japan
[5] Kurume Univ, Dept Community Med, Sch Med, 67 Asahi Machi, Kurume, Fukuoka 8300011, Japan
关键词
Idiopathic interstitial pneumonia; Acute exacerbation; COVID-19; vaccine; Tozinameran; Famtozinameran; DIAGNOSIS; UPDATE;
D O I
10.1016/j.rmcr.2023.101960
中图分类号
R56 [呼吸系及胸部疾病];
学科分类号
摘要
An 82-year-old man diagnosed with interstitial lung disease through computed tomography (CT) 1 year prior received a bivalent (tozinameran and famtozinameran) mRNA COVID-19 vaccine. He developed respiratory symptoms 1.5 months later, and chest high-resolution CT revealed new ground-glass opacities showing traction bronchiectasis. Transbronchial lung cryobiopsy revealed organizing acute lung injury and fibrosis with architectural destruction. The patient was diagnosed with an acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF). The bivalent mRNA COVID-19 vaccination was determined as the cause of the AE-IPF based on detailed medical history and examination findings. High-dose corticosteroid therapy improved the patient's symptoms and radiological findings.
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