Unraveling Ros Conversion Through Enhanced Enzyme-Like Activity with Copper-Doped Cerium Oxide for Tumor Nanocatalytic Therapy

被引:18
作者
Gu, Zhengxiang [1 ]
Zhong, Dan [1 ]
Hou, Xingyu [1 ]
Wei, Xuelian [1 ]
Liu, Caikun [2 ]
Zhang, Yechuan [3 ]
Duan, Zhenyu [1 ]
Gu, Zhongwei [1 ]
Gong, Qiyong [1 ,4 ]
Luo, Kui [1 ,4 ]
机构
[1] Sichuan Univ, West China Hosp,State Key Lab Biotherapy, Huaxi MR Res Ctr HMRRC,Dept Radiol, Frontiers Sci Ctr Dis Related Mol Network, Chengdu 610041, Peoples R China
[2] Sichuan Univ, Natl Engn Res Ctr Biomat, 29 Wangjiang Rd, Chengdu 610064, Peoples R China
[3] Nanjing Normal Univ, Sch Chem & Mat Sci, Nanjing 210023, Peoples R China
[4] Chinese Acad Med Sci, Res Unit Psychoradiol, Funct & Mol imaging Key Lab Sichuan Prov, Chengdu 610041, Peoples R China
基金
中国国家自然科学基金;
关键词
cerium oxide/copper; nanocatalytic therapy; nanozymes; oxygen vacancies; reactive oxygen species; CRYSTAL-PLANE; ELECTROCHEMICAL REDUCTION; CO2; VACANCIES; PROTEINS; NO;
D O I
10.1002/advs.202307154
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Nanozyme catalytic therapy for cancer treatments has become one of the heated topics, and the therapeutic efficacy is highly correlated with their catalytic efficiency. In this work, three copper-doped CeO2 supports with various structures as well as crystal facets are developed to realize dual enzyme-mimic catalytic activities, that is superoxide dismutase (SOD) to reduce superoxide radicals to H2O2 and peroxidase (POD) to transform H2O2 to center dot OH. The wire-shaped CeO2/Cu-W has the richest surface oxygen vacancies, and a low level of oxygen vacancy (Vo) formation energy, which allows for the elimination of intracellular reactive oxygen spieces (ROS) and continuous transformation to center dot OH with cascade reaction. Moreover, the wire-shaped CeO2/Cu-W displays the highest toxic center dot OH production capacity in an acidic intracellular environment, inducing breast cancer cell death and pro-apoptotic autophagy. Therefore, wire-shaped CeO2/Cu nanoparticles as an artificial enzyme system can have great potential in the intervention of intracellular ROS in cancer cells, achieving efficacious nanocatalytic therapy. A high degree of surface oxygen mobility and a low level of oxygen vacancy formation energy is exposed over the CeO2/Cu-W surface, which is employed as a mimetic enzyme of superoxide dismutase (SOD) to convert O2 center dot- -> H2O2 and peroxidase (POD) to realize H2O2 ->center dot OH for oncotherapy.image
引用
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页数:12
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