GABAergic signaling in alcohol use disorder and withdrawal: pathological involvement and therapeutic potential

被引：15

作者：

Dharavath, Ravinder Naik ^{[1
]}

Pina-Leblanc, Celeste ^{[1
,2
]}

Tang, Victor M. ^{[1
,3
,4
,5
,7
,8
]}

Sloan, Matthew E. ^{[1
,2
,4
,5
,6
,7
,8
]}

Nikolova, Yuliya S. ^{[1
,3
]}

Pangarov, Peter ^{[1
]}

Ruocco, Anthony C. ^{[1
,3
,9
,10
]}

Shield, Kevin ^{[8
]}

Voineskos, Daphne ^{[1
,3
,9
]}

Blumberger, Daniel M. ^{[1
,3
,9
]}

Boileau, Isabelle ^{[1
,2
,3
,11
]}

Bozinoff, Nikki ^{[1
,12
]}

Gerretsen, Philip ^{[1
,3
,7
,11
]}

Vieira, Erica ^{[1
,3
]}

Melamed, Osnat C. ^{[1
,12
]}

Sibille, Etienne ^{[1
,2
,3
]}

Quilty, Lena C. ^{[1
,3
]}

Prevot, Thomas D. ^{[1
,3
]}

机构：

[1] Campbell Family Mental Hlth Res Inst CAMH, Toronto, ON, Canada

[2] Univ Toronto, Dept Pharmacol & Toxicol, Toronto, ON, Canada

[3] Univ Toronto, Dept Psychiat, Toronto, ON, Canada

[4] CAMH, Addict Div, Toronto, ON, Canada

[5] Univ Toronto, Dept Psychiat, Div Neurosci & Clin Translat, Toronto, ON, Canada

[6] Univ Toronto Scarborough, Dept Psychol Clin Sci, Toronto, ON, Canada

[7] Univ Toronto, Inst Med Sci, Toronto, ON, Canada

[8] CAMH, Inst Mental Hlth Policy Res, Toronto, ON, Canada

[9] CAMH, Temerty Ctr Therapeut Brain Intervent, Toronto, ON, Canada

[10] Univ Toronto Scarborough, Dept Psychol, Toronto, ON, Canada

[11] CAMH, Brain Hlth Imaging Ctr, Toronto, ON, Canada

[12] Univ Toronto, Dept Family & Community Med, Toronto, ON, Canada

来源：

FRONTIERS IN NEURAL CIRCUITS | 2023年 / 17卷

关键词：

alcohol use disorders; clinical trials; GABA; integrative approach; interventions; pharmacotherapy; translational; unmet need; POSITIVE ALLOSTERIC MODULATOR; TRANSCRANIAL MAGNETIC STIMULATION; VENTRAL TEGMENTAL AREA; RECEPTOR-MEDIATED NEUROTRANSMISSION; VOLUNTARY ETHANOL INTAKE; GAMMA-AMINOBUTYRIC-ACID; GABA(B) RECEPTOR; CORTICAL INHIBITION; CENTRAL AMYGDALA; RECENT DRINKING;

D O I：

10.3389/fncir.2023.1218737

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Alcohol is one of the most widely used substances. Alcohol use accounts for 5.1% of the global disease burden, contributes substantially to societal and economic costs, and leads to approximately 3 million global deaths yearly. Alcohol use disorder (AUD) includes various drinking behavior patterns that lead to short-term or long-lasting effects on health. Ethanol, the main psychoactive molecule acting in alcoholic beverages, directly impacts the GABAergic system, contributing to GABAergic dysregulations that vary depending on the intensity and duration of alcohol consumption. A small number of interventions have been developed that target the GABAergic system, but there are promising future therapeutic avenues to explore. This review provides an overview of the impact of alcohol on the GABAergic system, the current interventions available for AUD that target the GABAergic system, and the novel interventions being explored that in the future could be included among first-line therapies for the treatment of AUD.

引用

页数：19

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