Alterations of Audiovisual Integration in Alzheimer's Disease

被引：2

作者：

Liu, Yufei ^{[1
,2
]}

Wang, Zhibin ^{[1
,2
]}

Wei, Tao ^{[1
,2
]}

Zhou, Shaojiong ^{[1
,2
]}

Yin, Yunsi ^{[1
,2
]}

Mi, Yingxin ^{[1
,2
]}

Liu, Xiaoduo ^{[1
,2
]}

Tang, Yi ^{[1
,2
]}

机构：

[1] Capital Med Univ, Xuanwu Hosp, Natl Ctr Neurol Disorders, Dept Neurol, Beijing 100053, Peoples R China

[2] Capital Med Univ, Xuanwu Hosp, Innovat Ctr Neurol Disorders, Natl Ctr Neurol Disorders, Beijing 100053, Peoples R China

来源：

NEUROSCIENCE BULLETIN | 2023年 / 39卷 / 12期

基金：

中国国家自然科学基金;

关键词：

Audiovisual integration; Aging; Alzheimer's disease; Cognition; Sensory information process; MILD COGNITIVE IMPAIRMENT; AGE-RELATED-CHANGES; MULTISENSORY INTEGRATION; WORKING-MEMORY; BRAIN-REGIONS; NEUROFIBRILLARY TANGLES; FUNCTIONAL CONNECTIVITY; SELECTIVE ATTENTION; SENSORY IMPAIRMENT; CROSSMODAL BINDING;

D O I：

10.1007/s12264-023-01125-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Audiovisual integration is a vital information process involved in cognition and is closely correlated with aging and Alzheimer's disease (AD). In this review, we evaluated the altered audiovisual integrative behavioral symptoms in AD. We further analyzed the relationships between AD pathologies and audiovisual integration alterations bidirectionally and suggested the possible mechanisms of audiovisual integration alterations underlying AD, including the imbalance between energy demand and supply, activity-dependent degeneration, disrupted brain networks, and cognitive resource overloading. Then, based on the clinical characteristics including electrophysiological and imaging data related to audiovisual integration, we emphasized the value of audiovisual integration alterations as potential biomarkers for the early diagnosis and progression of AD. We also highlighted that treatments targeted audiovisual integration contributed to widespread pathological improvements in AD animal models and cognitive improvements in AD patients. Moreover, investigation into audiovisual integration alterations in AD also provided new insights and comprehension about sensory information processes.

引用

页码：1859 / 1872

页数：14

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