Exosomes-mediated tumor metastasis through reshaping tumor microenvironment and distant niche

被引：39

作者：

Luo, Xinyi ^{[1
]}

Li, Yang ^{[1
]}

Hua, Zhenglai ^{[1
]}

Xue, Xiaoxia ^{[1
]}

Wang, Xiangpeng ^{[1
]}

Pang, Mingshi ^{[1
]}

Xiao, Cheng ^{[2
]}

Zhao, Hongyan ^{[3
]}

Lyu, Aiping ^{[4
]}

Liu, Yuanyan ^{[1
]}

机构：

[1] Beijing Univ Chinese Med, Sch Mat Med, Beijing 100029, Peoples R China

[2] China Japan Friendship Hosp, Inst Clin Med, Beijing, Peoples R China

[3] China Acad Chinese Med Sci, Expt Res Ctr, Beijing Key Lab Res Chinese Med Prevent & Treatmen, Beijing, Peoples R China

[4] Hong Kong Baptist Univ, Sch Chinese Med, Hong kong, Peoples R China

来源：

JOURNAL OF CONTROLLED RELEASE | 2023年 / 353卷

基金：

中国国家自然科学基金;

关键词：

Tumor-derived exosomes; Tumor microenvironment; Pre-metastatic niche; Metastasis; Prediction; EXTRACELLULAR VESICLES; CANCER CELLS; MESENCHYMAL TRANSITION; MOLECULAR-MECHANISMS; MEMBRANE-SCISSION; T-CELLS; HYPOXIA; INFLAMMATION; ESCAPE; LUNG;

D O I：

10.1016/j.jconrel.2022.11.050

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Tumor-derived exosomes (TDEs) are the particular communicator and messenger between tumor cells and other cells containing cancer-associated genetic materials and proteins. And TDEs who are also one of the important components consisting of the tumor microenvironment (TME) can reshape and interact with TME to promote tumor development and metastasis. Moreover, due to their long-distance transmission by body fluids, TDEs can facilitate the formation of pre-metastatic niche to support tumor colonization. We discuss the main character-istics and mechanism of TDE-mediated tumor metastasis by reshaping TME and pre-metastatic niche as well as the potential of TDEs for diagnosing tumor and predicting future metastatic development.

引用

页码：327 / 336

页数：10

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