Estimated small dense low-density lipoprotein-cholesterol and incident type 2 diabetes in Japanese people: Population-based Panasonic cohort study 13

被引：5

作者：

Ichikawa, Takahiro ^{[1
]}

Okada, Hiroshi ^{[1
,2
]}

Hamaguchi, Masahide ^{[1
]}

Kurogi, Kazushiro ^{[3
]}

Murata, Hiroaki ^{[4
]}

Ito, Masato ^{[3
]}

Fukui, Michiaki ^{[1
]}

机构：

[1] Kyoto Prefectural Univ Med, Grad Sch Med Sci, Dept Endocrinol & Metab, 465 Kajii Cho, Kawaramachi Hirokoji,Kamigyo Ku, Kyoto 6028566, Japan

[2] Matsushita Mem Hosp, Dept Diabet & Endocrinol, 5-55 Sotojima Cho, Moriguchi 5708540, Japan

[3] Panason Hlth Insurance Org, Dept Hlth Care Ctr, 5-55 Sotojima Cho, Moriguchi 5708540, Japan

[4] Matsushita Mem Hosp, Dept Orthopaed Surg, 5-55 Sotojima Cho, Moriguchi 5708540, Japan

来源：

DIABETES RESEARCH AND CLINICAL PRACTICE | 2023年 / 199卷

关键词：

LDL cholesterol; Diabetes; Japanese; Cohort; INSULIN-RESISTANCE; LDL;

D O I：

10.1016/j.diabres.2023.110665

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Aims: This study aimed to investigate the association between estimated small dense low-density lipoprotein (sdLDL) and incident type 2 diabetes.Methods: We analyzed the data from a health checkup under a program conducted by Panasonic Corporation between 2008 and 2018. A total of 120,613 participants were included, of whom 6,080 developed type 2 diabetes. Estimated large buoyant (lb)-LDL cholesterol and sd-LDL cholesterol was calculated by the formula using triglyceride and LDL cholesterol. Cox proportional hazard model and time-dependent receiver operating characteristic (ROC) analysis were used to evaluate the association between the lipid profiles and incident type 2 diabetes.Results: Multivariate analysis showed that LDL cholesterol, high-density lipoprotein (HDL) cholesterol, triglyceride, estimated large buoyant (lb)-LDL cholesterol, and estimated sd-LDL were associated with incident type 2 diabetes. Moreover, the area under the ROC curve and optimal cut-off values for estimated sd-LDL cholesterol for incident type 2 diabetes at 10 years were 0.676 and 35.9 mg/dL, respectively. The area under the curve of estimated sd-LDL cholesterol was higher than that of HDL cholesterol, LDL cholesterol, or estimated lb-LDL cholesterol.Conclusion: The estimated sd-LDL cholesterol was an important predictor of future incidence of diabetes within 10 years.

引用

页数：6

共 35 条

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