HIF-1 ACTIVATION AND INFLAMMATORY RESPONSES TO HYPOXIA

Acute hypoxia is a significant physiological danger during high-altitude flying and military aircraft missions. The human brain requires a constant supply of oxygen to function properly. It is consequently susceptible to settings with low availability of air oxygen. At high altitude, the decreased barometric pressure (hypobaria) decreases the partial pressure of inspired oxygen (PiO2), resulting in hypoxic hypoxia, henceforth referred to as hypoxia. The subsequent hypoxemia induces a metabolic shock that inhibits brain function and, as its severity increases, leads to loss of consciousness and death. For instance, an inboard leak within a pressurised cabin or when ascending in an unpressurized aircraft beyond 10,000 feet, hypoxia may develop gradually (Shaw et al., 2021). © 2023, International Journal of Aviation, Aeronautics, and Aerospace. All Rights Reserved.