The breast cancer microenvironment and lipoprotein lipase: Another negative notch for a beneficial enzyme?

被引：5

作者：

Bavis, Makayla M. ^{[1
]}

Nicholas, Allison M. ^{[1
]}

Tobin, Alexandria J. ^{[1
]}

Christian, Sherri L. ^{[1
]}

Brown, Robert J. ^{[1
]}

机构：

[1] Mem Univ Newfoundland, Dept Biochem, 45 Arctic Ave, St John, NF A1C 5S7, Canada

来源：

FEBS OPEN BIO | 2023年 / 13卷 / 04期

基金：

加拿大自然科学与工程研究理事会;

关键词：

breast cancer; estrogen receptor; human epidermal growth factor receptor 2; lipase maturation factor; lipoprotein lipase; progesterone receptor; FATTY-ACID-METABOLISM; SURVIVAL ANALYSIS; HYDROLYSIS; MACROPHAGES; ACTIVATION; EXPRESSION; MECHANISM; PATHWAY; CELLS; ENTRY;

D O I：

10.1002/2211-5463.13559

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The energy demand of breast cancers is in part met through the beta-oxidation of exogenous fatty acids. Fatty acids may also be used to aid in cell signaling and toward the construction of new membranes for rapidly proliferating tumor cells. A significant quantity of fatty acids comes from the hydrolysis of lipoprotein triacylglycerols and phospholipids by lipoprotein lipase (LPL). The lipid obtained via LPL in the breast tumor microenvironment may thus promote breast tumor growth and development. In this hypothesis article, we introduce LPL, provide a meta-analysis of RNAseq data showing that LPL is associated with poor prognosis, and explain how LPL might play a role in breast cancer prognosis over time.

引用

页码：586 / 596

页数：11

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