Convalescent Plasma Therapy in Immunocompromised Patients Infected With the BA.1 or BA.2 Omicron SARS-CoV-2

被引：0

作者：

Richier, Quentin ^{[1
]}

De Valence, Benjamin ^{[1
]}

Chopin, Dorothee ^{[1
]}

Gras, Emmanuelle ^{[1
,2
]}

Levi, Laura I. ^{[1
,2
]}

Aad, Yasmine Abi ^{[1
]}

Pacanowski, Jerome ^{[1
]}

Meynard, Jean-Luc ^{[1
]}

Placais, Leo ^{[3
]}

Fey, Dorothee ^{[1
]}

Couture, Priscille ^{[4
]}

Martin-Blondel, Guillaume ^{[5
,6
,7
]}

Pestre, Vincent ^{[8
]}

Woessner, Juliette ^{[8
]}

Ancellin, Sophie ^{[9
]}

Weyrich, Pierre ^{[10
]}

Carpentier, Benjamin ^{[10
]}

Idri, Salim ^{[11
]}

Tiberghien, Pierre ^{[12
,13
]}

Surgers, Laure ^{[1
,2
]}

Hueso, Thomas ^{[14
]}

Lacombe, Karine ^{[1
,2
]}

机构：

[1] Hop St Antoine, AP HP, Serv Malad Infect, Paris, France

[2] Sorbonne Univ, Inserm UMR S1136, IPLESP, Paris, France

[3] Hop Bicetre, Dept Med Interne & Immunol Clin, Le Kremlin Bicetre, France

[4] Hop Foch, Serv Med Interne, Suresnes, France

[5] Ctr Hosp Univ Toulouse, Serv Malad Infect & Trop, F-31300 Toulouse, France

[6] Ctr Physiopathol Toulouse Purpan, INSERM UMR1043, Toulouse, France

[7] Univ Toulouse Paul Sabatier, Fac Med, Toulouse, France

[8] Ctr Hosp Avignon, Serv Med Interne & Malad Infect, Avignon, France

[9] Ctr Hosp Auch, Auch, France

[10] Grp Hop Catholiques Lille, Unite Infectiol, F-59160 Lille, France

[11] Etab Francais Sang, Creteil, France

[12] Etab Francais Sang, La Plaine St Denis, France

[13] UMR 1098 RIGHT Inserm Univ Franche Comte, Etab Francais Sang, Besancon, France

[14] Sorbonne Paris Nord Univ, Hop Avicenne, Serv Radiol, Serv Hematol Clin, Bobigny, France

来源：

INFLUENZA AND OTHER RESPIRATORY VIRUSES | 2024年 / 18卷 / 03期

关键词：

convalescent plasma; COVID-19; immunocompromised; Omicron variant; SARS-CoV-2;

D O I：

10.1111/irv.13272

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The emergence of SARS-CoV-2 Omicron variant has led to a complete reconfiguration of the therapeutic landscape, with all monoclonal antibodies having lost any neutralization activity. We report here a case series of 75 immunocompromised patients infected by the Omicron variant who benefited from COVID-19 convalescent plasma (CCP). At Day 28, the overall survival was 76% (95% CI 67-86) with no significant difference in the clinical outcome between patients with hematological malignancies, solid organ transplantation or autoimmune diseases. No safety concern was reported during the course of the study. These results showed that CCP is well tolerated and represents a treatment option for immunocompromised patients who remain highly impacted by the COVID19 epidemic.

引用

页数：5

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