Development and Evaluation of Fenofibrate Surface Solid Dispersion for Improved Solubility and Dissolution Rate

被引:0
作者
Hosmani, Avinash Hanmant [1 ,5 ]
Patil, Nikhil Dilip [2 ]
Pawar, Arti Achut [1 ]
Honmane, Sandip Mohan [3 ,6 ]
Thorat, Yogesh Shripad [4 ]
机构
[1] Shivaji Univ, Govt Coll Pharm, Dept Pharmaceut, Kolhapur, Maharashtra, India
[2] Shivaji Univ, Annasaheb Dange Coll B Pharm, Dept Pharmacognosy, Kolhapur, Maharashtra, India
[3] Shivaji Univ, Annasaheb Dange Coll B Pharm, Dept Pharmaceut, Kolhapur, Maharashtra, India
[4] DSTS Mandals Coll Pharm, Dept Pharmaceut, Solapur, Maharashtra, India
[5] Govt Coll Pharm, Dept Pharmaceut, Karad 415124, Maharashtra, India
[6] Annasaheb Dange Coll B Pharm, Dept Pharmaceut, Ashta 416301, Maharashtra, India
关键词
FNB; Surface solid dispersion; Solvent evaporation; Solubility; Dissolution rate;
D O I
10.5530/ijper.58.2.50
中图分类号
G40 [教育学];
学科分类号
040101 ; 120403 ;
摘要
Objectives: The current work aimed to prepare and characterize Surface-Solid Dispersion (SSD) of Fenofibrate (FNB) in order to improve its solubility and dissolution. Materials and Methods: SSD of FNB has been prepared using solvent evaporation techniques through the combination of hydrophilic polymers such as Aerosil 200, Avicel PH 101, Sodium Starch Glycolate (SSG), Crospovidone (CP) and Croscarmellose Sodium (CCS). The produced SSDs were tested for saturation solubility, production yield, Fourier-Transform Infrared Spectroscopy (FTIR), Powder X-ray Diffraction (PXRD), Differential Scanning Calorimetry (DSC), Scanning Electron Microscopy (SEM), and in vitro dissolution study. Results: PXRD results demonstrated a conversion of the crystalline FNB to an amorphous state when formulated with the carrier, which improved FNB solubility. A decrease in the endothermic peak with respect to FNB in the DSC thermogram of SSD, confirms the loss of crystallinity. Hydrophilic carriers such as Aerosil 200 and CCS at 1:2 (drug: polymer) ratios were found to increase solubility by 3 fold. Conclusion: As a result, the creation of SSD using hydrophilic polymers (Aerosil 200 and CCS) by solvent evaporation seemed to be a novel method that enhanced FNB solubility and dissolution.
引用
收藏
页码:446 / 452
页数:7
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