A new ultrasound-assisted microextraction for elemental impurities determination in tablets by ICP-MS according to USP chapters 232 and 233

被引：2

作者：

Noronha, Igor Forattini Prates C. ^{[1
]}

Pinheiro, Fernanda C. ^{[1
]}

Nascentes, Clesia C. ^{[1
]}

机构：

[1] Univ Fed Minas Gerais, Dept Chem, ICEX, Ave Presidente Antonio Carlos, 6627, BR-31270901 Belo Horizonte, MG, Brazil

来源：

TALANTA | 2024年 / 271卷

关键词：

Cup horn; ICP-MS; Sample preparation; Tablets; Quality control; ACTIVE PHARMACEUTICAL INGREDIENTS; SPECTROMETRY; EXTRACTION; PRODUCTS;

D O I：

10.1016/j.talanta.2023.125604

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Along with the United States Pharmacopeia (USP) chapters 232 and 233 regarding elemental impurities in pharmaceutical products, new challenges have been imposed in terms of sample preparation procedures prior to inductively coupled plasma mass spectrometry analysis, considering the matrix complexities. As so, a new microextraction procedure assisted by ultrasound using a cup-horn sonoreactor, minimal reactants, and sample was proposed and validated according to USP. The procedure was optimized with samples of milled tablets and 3 different acid mixtures (HNO3, 3HNO(3):1HCl, and 9HNO(3):1HF) and it was compared with microwave-assisted acid digestion. In the validation step, recoveries ranging from 85 to 120 % and RSD below 10 % were obtained for 22 analytes (except Ag and Pt) with satisfactory linearity and good sensitivity. The method was then applied for 37 samples of antidepressants, which presented trace levels of As, Ba, Cd, Co, Cr, Cu, Ni, Pb, Pd, Sn, and V.

引用

页数：9

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