Antioxidant and Hypoglycemic Potential of Essential Oils in Diabetes Mellitus and Its Complications

被引:18
作者
Bungau, Simona Gabriela [1 ,2 ]
Vesa, Cosmin Mihai [1 ,3 ]
Bustea, Cristian [4 ]
Purza, Anamaria Lavinia [2 ]
Tit, Delia Mirela [1 ,2 ]
Brisc, Mihaela Cristina [5 ]
Radu, Andrei-Flavius [1 ,3 ]
机构
[1] Univ Oradea, Doctoral Sch Biomed Sci, Oradea 410087, Romania
[2] Univ Oradea, Fac Med & Pharm, Dept Pharm, Oradea 410028, Romania
[3] Univ Oradea, Fac Med & Pharm, Dept Preclin Disciplines, Oradea 410073, Romania
[4] Oradea Cty Emergency Clin Hosp, Dept Surg, Oradea 410169, Romania
[5] Univ Oradea, Fac Med & Pharm, Dept Med Disciplines, Oradea 410073, Romania
关键词
antioxidants; essential oil; diabetes mellitus; phytochemistry; bibliometric analysis; SALVIA-OFFICINALIS L; NIGELLA-SATIVA OIL; OXIDATIVE STRESS; MEDICINAL-PLANTS; CUMINUM-CYMINUM; ALPHA-AMYLASE; INSULIN; GLUCOSE; EXTRACTS; ANTIBACTERIAL;
D O I
10.3390/ijms242216501
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Since the earliest times, essential oils (EOs) have been utilized for medicinal and traditional purposes. However, in recent decades, an increasing interest has developed due to the need to rediscover herbal remedies and adjuvant therapies for the management of various diseases, particularly chronic ones. The present narrative review examines the potential for EOs to exert hypoglycemic and antioxidant effects in diabetes mellitus, analyzing the main publications having evaluated plant species with potentially beneficial effects through their phytocompounds in diabetes mellitus and its complications. Numerous species have shown promising characteristics that can be used in diabetes management. The hypoglycemic effects of these EOs are attributed to their capacity to stimulate glucose uptake, suppress glucose production, and increase insulin sensitivity. Moreover, EOs can alleviate the oxidative stress by manifesting their antioxidant effects via a variety of mechanisms, including the scavenging of free radicals, the regulation of antioxidant enzymes, and the decreasing of lipid peroxidation, due to their diverse chemical composition. These findings demonstrate the possible benefits of EOs as adjuvant therapeutic agents in the management of diabetes and its complications. The use of EOs in the treatment of diabetes shows good potential for the development of natural and effective strategies to enhance the health outcomes of people with this chronic condition, but additional experimental endorsements are required.
引用
收藏
页数:22
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