Meropenem/Vaborbactam: β-Lactam/β-Lactamase Inhibitor Combination, the Future in Eradicating Multidrug Resistance

被引：15
作者：
Duda-Madej, Anna [1 ]
Viscardi, Szymon [2 ]
Topola, Ewa [2 ]
机构：
[1] Wroclaw Med Univ, Fac Med, Dept Microbiol, Chalubinskiego 4, PL-50368 Wroclaw, Poland
[2] Wroclaw Med Univ, Fac Med, Ludw Pasteura 1, PL-50367 Wroclaw, Poland
来源：
ANTIBIOTICS-BASEL | 2023年 / 12卷 / 11期
关键词：
beta-lactam/beta-lactamase inhibitor; carbapenem-resistant Enterobacterales (CRE); Klebsiella pneumoniae carbapenemase (KPC); meropenem; multidrug resistance; vaborbactam; URINARY-TRACT-INFECTION; MEROPENEM-VABORBACTAM; ENTEROBACTERIACEAE; RPX7009; PREVENTION; PNEUMONIA; STABILITY;
D O I：
10.3390/antibiotics12111612
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Due to the fact that there is a steadily increasing trend in the area of antimicrobial resistance in microorganisms, there is a need to look for new treatment alternatives. One of them is the search for new beta-lactamase inhibitors and combining them with beta-lactam antibiotics, with the aim of increasing the low-dose efficacy, as well as lowering the resistance potential of bacterial strains. This review presents the positive effect of meropenem in combination with a vaborbactam (MER-VAB). This latest antibiotic-inhibitor combination has found particular use in the treatment of infections with the etiology of carbapenem-resistant Enterobacterales (CRE), Gram-negative bacteria, with a high degree of resistance to available antimicrobial drugs.
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页数：17
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