The role of hypoxia-inducible factors in breast cancer stem cell specification

被引：7

作者：

Fath, Mohsen Karami ^{[1
]}

Garousi, Setareh ^{[2
]}

Mottahedi, Mehran ^{[2
]}

Ghasemzadeh, Nasim ^{[3
]}

Salmani, Kiana ^{[4
]}

Olfati, Fatemeh ^{[5
]}

Saeed, Miad Beit ^{[6
]}

Sotoudeh, Sina ^{[7
]}

Barati, Ghasem ^{[8
]}

机构：

[1] Kharazmi Univ, Fac Biol Sci, Dept Cellular & Mol Biol, Tehran, Iran

[2] Mashhad Univ Med Sci, Fac Med, Mashhad, Iran

[3] Collin Coll, McKinney, TX USA

[4] Islamic Azad Univ, Fac Adv Sci & Technol, Dept Genet, Tehran Med Sci, Tehran, Iran

[5] Univ Tehran Med Sci, Fac Nursing & Midwifery, Dept Reprod Hlth, Tehran, Iran

[6] Abadan Islamic Azad Univ, Fac Nursing & Midwifery, Abadan, Iran

[7] Guilan Univ Med Sci, Fac Nursing & Midwifery, Guilan, Iran

[8] Stem Cell Technol Res Ctr, Tehran, Iran

来源：

PATHOLOGY RESEARCH AND PRACTICE | 2023年 / 243卷

关键词：

Breast cancer; Hypoxia-inducible factors; Hypoxia; Cancer stem cells; Cancer targeted therapy; Stemness maintenance; ACUTE MYELOID-LEUKEMIA; TUMOR PROGRESSION; STRUCTURAL BASIS; NONCODING RNAS; RISK-FACTORS; EXPRESSION; NANOG; MAINTENANCE; CD44; TRANSCRIPTION;

D O I：

10.1016/j.prp.2023.154349

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Breast tumor is heterogeneous cancer with high morbidity and mortality rates, particularly in developing countries. Despite new efforts to reduce the breast cancer implications, the number of newly diagnosed cases is increasing worldwide. It is believed that cancer stem cells (CSCs) are responsible for the implication of cancers including breast cancer. Although CSCs compose a small population in tumor bulks, they play a crucial role in tumor initiation, progression, metastasis, and chemotherapeutic resistance. These events are mediated by the hypoxia-inducible factor (HIF) pathway which regulates the transcription of genes involved in CSC maintenance and tumorigenesis. In this review, we discussed the mechanisms by which hypoxia-or chemotherapy-induced HIFs promote breast CSC specification.

引用

页数：10