In platelet single donor apheresis, platelet factor 4 levels correlated with donor's age and decreased during storage

被引：3
作者：
Duchez, Anne Claire [1 ,2 ]
Heestermans, Marco [1 ,2 ]
Arthaud, Charles-Antoine [1 ,2 ]
Eyraud, Marie-Ange [1 ,2 ]
Portier, Mailys [1 ,2 ]
Prier, Amelie [1 ,2 ]
Hamzeh-Cognasse, Hind [1 ]
Cognasse, Fabrice [1 ,2 ]
机构：
[1] Univ Jean Monnet, INSERM, Mines St Etienne, U1059 SAINBIOSE, F-42023 St Etienne, France
[2] Estab Francais du Sang Auvergne Rhone Alpes, 25 Blvd Pasteur, F-42100 St Etienne, France
来源：
SCIENTIFIC REPORTS | 2024年 / 14卷 / 01期
关键词：
ADVERSE-REACTIONS; PLASMA-LEVELS; ACTIVATION; RELEASE;
D O I：
10.1038/s41598-024-56826-4
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The human population is ageing worldwide. The World Health Organization estimated that the world's population of people aged 60 years and older will increase to at least 30%, coinciding with a growing frequency of cognitive and cardiovascular disease. Recently, in preclinical studies platelet Factor 4 (PF4) was presented as a pro-cognitive factor. This molecule is released by platelets in the circulation and could be present in blood products destined for transfusion. We wondered if PF4 levels are correlated to the age of the blood donor or to the storage time of platelet concentrates (PCs) intended for transfusion? We observed higher levels of PF4 in PCs from elderly donors compared to younger donors, while PC storage time did not determine PF4 levels expression.
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页数：7
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